gene

PSMC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

8Outgoing

6Incoming

0Experiments

0Debates

Summary

PSMC1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, implicated in. Associated with Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PSMC1
Full Name	Proteasome 26S Subunit, ATPase 1
Aliases	Proteasome 26S Subunit ATPase 1
Chromosome	19q13.33
Protein Type	Protease
Function	PSMC1 (Proteasome 26S Subunit, ATPase 1) encodes a member of the ATPase family that functions as a regulatory subunit of the 26S proteasome.
Primary Expression	all tissues, with high expression in brain, particularly in neurons of the cerebral cortex, [hippocampus](/brain-regions/hipp
Subcellular Localization	both cytosolic and nuclear compartments, consistent with its role in cytosolic and nuclear protein degradation [7](https
Pathways	Autophagy, Proteasome
UniProt ID	PSMC1
Ensembl ID	ENSG00000121039
GeneCards	PSMC1
Human Protein Atlas	PSMC1
Associated Diseases	neurodegeneration
KG Connections	14 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PSMC1 (Proteasome 26S Subunit ATPase 1)

gene · 606 words

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Pathway Diagram

graph TD
    PSMC1["PSMC1"]
    Ms{"Ms"}
    PSMC1 -->|"interacts with"| Ms
    AMBRA1["AMBRA1"]
    PSMC1 -->|"regulates"| AMBRA1
    DDX20["DDX20"]
    PSMC1 -->|"regulates"| DDX20
    AUTOPHAGY["AUTOPHAGY"]
    PSMC1 -->|"regulates"| AUTOPHAGY
    Proteasome(["Proteasome"])
    PSMC1 -->|"regulates"| Proteasome
    Autophagy(["Autophagy"])
    PSMC1 -->|"regulates"| Autophagy
    Immune_Response(["Immune Response"])
    PSMC1 -->|"interacts with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    PSMC1 -->|"implicated in"| neurodegeneration
    PSMB1["PSMB1"]
    PSMB1 -->|"associated with"| PSMC1
    PSMA3["PSMA3"]
    PSMA3 -->|"regulates"| PSMC1
    style PSMC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
AUTOPHAGY	regulates	gene	0.60
Proteasome	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
Immune Response	interacts_with	pathway	0.60
AMBRA1	regulates	gene	0.60
DDX20	regulates	gene	0.60
RPL5	regulates	gene	0.60

Incoming (6)

Source	Relation	Type	Str
genes-psmc1	documents	wiki_page	1.00
genes-psmc1	describes	wiki_page	1.00
PSMB1	associated_with	gene	0.80
CXCR4	regulates	gene	0.60
CCL2	regulates	gene	0.60
PSMA3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMC1 in their description or question text

No additional research found