gene

ANO3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANO3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

17Outgoing

2Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	ANO3
Protein Type	Channel
Function	is a gene encoding a calcium-activated chloride channel protein.
Primary Expression	the basal ganglia, cortex, and cerebellum, consistent with its r
Amino Acids	982 aa
Ensembl ID	ENSG00000162836
GeneCards	ANO3
Human Protein Atlas	ANO3
Eight transmembrane domains	Spanning the plasma membrane
Calcium-binding domain	Intracellular C-terminus contains calcium-binding sites
Phospholipid scramblase domain	May facilitate lipid movement across membrane
Dimerization capability	Functional channels form as homodimers or heterodimers
Striatum	High expression in medium spiny neurons (MSNs)
Globus pallidus	Both internal and external segments
Substantia nigra	Pars compacta and pars reticulata
Associated Diseases	Als, Alzheimer, dementia, neurodegeneration
Interactions	RBFOX1
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ANO3 Gene

gene · 1397 words

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Pathway Diagram

graph TD
    ANO3["ANO3"] -->|"regulates"| TREM2["TREM2"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANO3["ANO3"] -->|"regulates"| APOE["APOE"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANO3["ANO3"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ANO3["ANO3"] -->|"contributes to"| ANXIETY["ANXIETY"]
    style ANXIETY fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANO3["ANO3"] -->|"associated"| GNAL["GNAL"]
    style GNAL fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANO3["ANO3"] -->|"contributes to"| DEPRESSION["DEPRESSION"]
    style DEPRESSION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANO3["ANO3"] -->|"associated"| TOR1A["TOR1A"]
    style TOR1A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GCH1["GCH1"] -->|"associated"| ANO3["ANO3"]
    style GCH1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    THAP1["THAP1"] -->|"associated"| ANO3["ANO3"]
    style THAP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ANO3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (17)

Target	Relation	Type	Str
TREM2	upregulates	gene	0.80
APOE	upregulates	gene	0.80
Als	associated_with	disease	0.65
ANXIETY	contributes_to	gene	0.60
DEPRESSION	contributes_to	gene	0.60
Actin	contributes_to	protein	0.60
neurons	expressed_in	cell_type	0.60
GNAL	associated_with	gene	0.60
TOR1A	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
amyloid aggregation	interacts_with	process	0.60
RBFOX1	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
FOXA2	co_expressed_with	gene	0.50
PSMA3	co_expressed_with	protein	0.50

Incoming (2)

Source	Relation	Type	Str
GCH1	associated_with	gene	0.60
THAP1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANO3 in their description or question text

No additional research found