gene

adcy8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adcy8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

1Analyses

16Outgoing

3Incoming

3Experiments

1Debates

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🧬 Gene Info

Gene Symbol	ADCY8
Chromosome	8q24.22
Function	ADCY8 plays essential roles in neuronal physiology:
Subcellular Localization	</th><td>Plasma membrane, dendritic membranes, postsynaptic densities</td></tr>
Molecular Weight	125 kDa
Exons	28
GeneCards	ADCY8
Human Protein Atlas	ADCY8
N-terminal extracellular domain	Involved in dimerization and membrane targeting
12 transmembrane helices	Organized into two sets of six (TM1-TM6 and TM7-TM12)
Calmodulin-binding domain	Located in the C1a region, mediates calcium/calmodulin activation
Associated Diseases	migratory distance, population-level migration differences
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADCY8 Protein

protein · 766 words

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Pathway Diagram

flowchart TD
    N0["ADCY8"]
    N1["AND"]
    N0 -->|"regulates"| N1
    N2["Ras"]
    N0 -->|"expressed in"| N2
    N3["App"]
    N0 -->|"expressed in"| N3
    N4["neurodegeneration"]
    N0 -->|"implicated in"| N4

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 protein
    class N3 protein

Outgoing (16)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY8	data_in	dataset_row	0.00
cAMP	produces	molecule	0.90
spatial_navigation	modulates	cognitive_function	0.90
migratory distance	associated_with	phenotype	0.85
long-term memory	involved_in	process	0.80
population-level migration differences	contributes_to	phenotype	0.79
hippocampus	regulates	brain_region	0.70
synaptic_plasticity	modulates	biological_process	0.70
adenylyl_cyclase_activity	enhances	biological_process	0.70
long_term_spatial_memory_formation	causes	phenotype	0.70
circadian_rhythms	couples_with	biological_process	0.70
epigenetic_programming	modulates	mechanism	0.70
navigation_disorders	protective_against	disease	0.70
Ras	expressed_in	protein	0.60
App	expressed_in	protein	0.60
AND	regulates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADCY8	data_in	dataset_row	0.00
long-term memory	drives	process	0.75
Falco peregrinus	expressed_in	cell_type	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does ADCY8 mechanistically regulate long-term memory formation in migratory

memory and navigation | 2026-04-08 | 0 hypotheses

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Score	Model	Status	Est. Cost
Genome resequencing and GWAS for migratory distance in peregrine falco	exploratory	0.850	wild peregrine falcons (Falco	proposed	N/A
Genome resequencing and association with migratory distance	exploratory	0.850	wild peregrine falcon populati	proposed	N/A
ADCY8 regulatory mechanism investigation	exploratory	0.750	peregrine falcon populations	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study identifies ADCY8 as associated with migratory distance differences and

closed · Rounds: 4 · Score: 0.95 · 2026-04-09