gene

GRIK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

7Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for GRIK3 - Glutamate Receptor Kainate Type Subunit 3

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🧬 Gene Info

Gene Symbol	GRIK3
Full Name	Glutamate Ionotropic Kainate Type Subunit 3
Aliases	Page for GRIK3, Page for GRIK3 Protein
Chromosome	1p36
Protein Type	Receptor
Function	GRIK3 encodes the GluR7 kainate receptor subunit:
Primary Expression	the brain and plays roles in synaptic transmission, neuronal excitability, and information processing
Molecular Weight	100 kDa
Amino Acids	890 aa
UniProt ID	Q9UHI5
NCBI Gene ID	2897
Ensembl ID	ENSG00000135720
OMIM	138245
GeneCards	GRIK3
Human Protein Atlas	GRIK3
Associated Diseases	neurodegeneration
Interactions	CANCER, ERK, GRID2, NEURON, PDGFRA, RAS
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GRIK3 — AlphaFold Q9UHI5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRIK3["GRIK3"]
    Cancer{"Cancer"}
    GRIK3 -->|"activates"| Cancer
    Tumor{"Tumor"}
    GRIK3 -->|"activates"| Tumor
    ERK["ERK"]
    GRIK3 -->|"activates"| ERK
    SRC["SRC"]
    GRIK3 -->|"activates"| SRC
    GRID2["GRID2"]
    GRIK3 -->|"activates"| GRID2
    PDGFRA["PDGFRA"]
    GRIK3 -->|"inhibits"| PDGFRA
    CANCER["CANCER"]
    GRIK3 -->|"activates"| CANCER
    AND["AND"]
    GRIK3 -->|"activates"| AND
    neurodegeneration["neurodegeneration"]
    GRIK3 -->|"implicated in"| neurodegeneration
    GRID2 -->|"activates"| GRIK3
    NEURON["NEURON"]
    NEURON -->|"activates"| GRIK3
    ERK -->|"activates"| GRIK3
    RAS["RAS"]
    RAS -->|"activates"| GRIK3
    style GRIK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
SRC	activates	gene	0.60
GRID2	activates	gene	0.60
PDGFRA	inhibits	gene	0.60
ERK	activates	gene	0.60
CANCER	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
GRID2	activates	gene	0.60
NEURON	activates	gene	0.60
ERK	activates	gene	0.60
RAS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIK3 in their description or question text

No additional research found