| Gene Symbol | P38 |
| Chromosome | MAPK14: 6p21.31, MAPK11: 22q13.13, MAPK12: 15q21.2, MAPK13: 6p21.31 |
| Protein Type | Kinase |
| Function | Upstream stress signals: Pro-inflammatory cytokines (IL-1β, TNF-α), oxidative stress, UV radiation, heat shock, and ischemia trigger activation |
| Primary Expression | neurons, microglia, and astrocytes |
| Molecular Weight | ~38-40 kDa per isoform |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Glycolysis |
| GeneCards | P38 |
| Human Protein Atlas | P38 |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Cancer, Carcinoma |
| Known Drugs/Compounds | Benzimidazole-aminopyrimidine hybrids, Gold nanoparticle, N-ACETYLCYSTEINE, p38α MAPK inhibitor, Paeoniflorin, RAPAMYCIN |
| Interactions | ACOX1, ACSL4, AGING, AHR, AIM2, AKT |
| KG Connections | 1672 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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