Contents

OSMR Gene

🧬 Gene Info

Gene Symbol	OSMR
Full Name	Oncostatin M Receptor
Chromosome	5p13.1
Protein Type	Receptor
Function	encodes a type I cytokine receptor that mediates signaling from IL-6 family cytokines, primarily Oncostatin M (OSM) and Leukemia Inhibitory Factor (LIF) [@breedlove2020].
Primary Expression	the CNS, with particularly high levels on reactive astrocytes surrounding sites of pathology
Molecular Weight	110 kDa
Amino Acids	979 aa
Exons	12
Pathways	MAPK, PI3K, PI3K pathway
UniProt ID	Q08357
NCBI Gene ID	9184
Ensembl ID	ENSG00000120708
OMIM	601095
GeneCards	OSMR
Human Protein Atlas	OSMR
Associated Diseases	Als, Alzheimer, Cancer Cachexia, Dementia, Inflammation, Ms
Interactions	Actin, ATP, AUTOPHAGY, Caspase, COX2, DRP1
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

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