Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNAPSE_ELIMINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| C1Q | regulates | protein | 0.87 |
| MICROGLIA | regulates | cell_type | 0.87 |
| COMPLEMENT | regulates | pathway | 0.72 |
| NPTX2 | inhibits | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina | 0.724 | neurodegeneration | How do the seven novel ALS genes functio |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Endothelium-specific TBK1 knockdown in atherosclerosis model | validation | atherosclerosis | 0.900 | 0.00 | endothelium-specific TBK1 knoc | proposed | N/A |
| TBK1-PAK1IP1-PAK1 signaling pathway analysis | exploratory | atherosclerosis | 0.900 | 0.00 | endothelial cells | proposed | N/A |
| GSK8612 treatment in atherosclerosis model | validation | atherosclerosis | 0.800 | 0.00 | atherosclerosis mouse model | proposed | N/A |
| LC-MS/Western blot analysis of TBK1 in atherosclerotic arteries | exploratory | atherosclerosis | 0.800 | 0.00 | mouse and human arteries with | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediat [PMID:40660474] | Li J, Yang Y, Ge Y, Zhang X, Liu H et al | Autophagy | 2026 | 0 |
| Aberrant STING signalling promotes endothelial dysfunction and neurovascular inj [PMID:41419617] | Qin X, Chen S, Sun Y, Ma Z, Niu C et al. | Diabetologia | 2026 | 0 |
| TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128] | Mordes DA, Smeyers J | Autophagy | 2026 | 0 |
| Dynamic regulation of TBK1 lactylation shapes antiviral immune responses. [PMID:41530535] | Xie Y, Zhang Y, Peng W, Zhang L, Hu Z et | Cell Mol Immunol | 2026 | 0 |
| RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250] | Naumann M, Wierschin TM, Kretschmer S, D | Adv Sci (Weinh) | 2026 | 0 |
| BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977] | Liu Q, Zhang X, Wang L, Chen H, Wang G e | Brain | 2026 | 0 |
| Systematic Review: Porphyromonas gingivalis Outer Membrane Vesicles From Pathoge [PMID:41980468] | Li Z, Luo C, Wen P, Zou T, Jin Z et al. | Int Dent J | 2026 | 0 |
| TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128] | Mordes DA, Smeyers J | Autophagy | 2026 | 0 |
| BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977] | Liu Q, Zhang X, Wang L, Chen H, Wang G, | Brain : a journal of neurology | 2026 | 0 |
| RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250] | Naumann M, Wierschin TM, Kretschmer S, D | Advanced science (Weinheim, Ba | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SYNAPSE_ELIMINATION in their description or question text
No additional research found