| Gene Symbol | RNF20 |
| Chromosome | 9q34.3 |
| Protein Type | Ligase |
| Function | RNF20 (Ring Finger Protein 20) is an E3 ubiquitin-protein ligase encoded by the RNF20 gene located on chromosome 9q34.3[@kim2009] |
| UniProt ID | Q5VTL2 |
| Ensembl ID | ENSG00000146727 |
| GeneCards | RNF20 |
| Human Protein Atlas | RNF20 |
| H2B ubiquitination | Catalyzes H2B K120ub1, a modification associated with active transcription[@minsky2008] |
| Transcriptional elongation | H2B-K120ub1 facilitates RNA Pol II passage through chromatin[@pavri2006] |
| DNA damage response | H2B ubiquitination promotes homologous recombination repair[@moyal2011] |
| p53 regulation | RNF20 modulates p53 activity through H2B ubiquitination[@shema2008] |
| Colorectal cancer | RNF20 frequently downregulated; tumor suppressor function[@tarcic2012] |
| Breast cancer | RNF20 expression correlates with prognosis; loss promotes metastasis[@zhang2015] |
| Gastric cancer | RNF20 reduced in aggressive subtypes[@liu2015] |
| Associated Diseases | neurodegeneration |
| Interactions | CRLS1, NCOR1, PIKFYVE, PPAR, RNA, SGMS1 |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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