| Gene Symbol | MDM4 (MDMX) |
| Full Name | MDM4 Proto-Oncogene |
| Chromosome | 1q32.1 |
| Function | MDM4 is a nuclear protein that contains a p53-binding domain and functions primarily as a transcriptional repressor[@toledo2007]: |
| Pathways | Epigenetic, Wnt signaling |
| UniProt ID | O15151 |
| NCBI Gene ID | 4193 |
| Ensembl ID | ENSG00000198625 |
| OMIM | 602673 |
| Direct Binding | MDM4 binds to p53 transactivation domain, inhibiting p53-mediated gene activation |
| Protein Stability | Unlike MDM2, MDM4 does not ubiquitinate p53; instead it stabilizes p53 protein |
| Feedback Regulation | p53 activates MDM4 expression, creating a balanced regulatory loop |
| G1/S Transition | MDM4 overexpression promotes G1/S cell cycle progression |
| S-Phase Entry | Modulates E2F1 activity for proper S-phase entry |
| Checkpoint Response | Negatively regulates p53-dependent cell cycle arrest |
| Associated Diseases | AD, ALI, Als, AMI, cancer |
| Interactions | AKT3, APOB, APOPTOSIS, CANCER, CDKN2A, DNA |
| KG Connections | 150 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!