protein 1,299 words KG: IL18
Contents

Interleukin-18 Protein

🔬 Protein Info
Gene SymbolIL18
Full NameInterleukin-18
Chromosome11q22.2-q22.3
FunctionGene expression: The IL18 gene is induced by NF-κB and AP-1 transcription factors in response to TLR ligands, TNF, and IL-1β
Subcellular Localization</b></td><td>Cytoplasm, Secreted</td></tr>
Molecular Weight24 kDa
Amino Acids192 aa
PathwaysNF-κB
UniProt ID[Q14116](https://www.uniprot.org/uniprot/Q14116)
Ensembl IDENSG00000150782
GeneCardsIL18
Human Protein AtlasIL18
Associated DiseasesAlcohol Use Disorder, ALS, Alzheimer, Fibrosis, Inflammation, Ms
InteractionsALZHEIMER, AMYLOID, Amyloid-Beta, AMYLOID-BETA, APOPTOSIS, ASC
KG Connections329 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Purinergic Signaling Polarization Control
Score: 0.71
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Microbial Inflammasome Priming Prevention
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ASC (PYCARD)
gene · KG edge: activates
ATG14 Gene
gene · KG edge: associated_with
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NLRP3_INFLAMMASOME produces IL18
IL1B associated_with IL18
IL18 associated_with CASP1
IL18 associated_with ATG5
IL18 associated_with NLRC4
IL18 associated_with ASC
IL18 associated_with NLRP3
IL18 associated_with PYCARD
IL18 associated_with TNF
IL18 associated_with RAMP1

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