gene

il1rn

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about il1rn: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

22Outgoing

11Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	IL1RN
Full Name	Interleukin 1 Receptor Antagonist
Chromosome	2q14.1
Function	encodes the IL-1 receptor antagonist (IL-1Ra), a naturally occurring 152-amino acid secreted glycoprotein
Amino Acids	152 aa
Pathways	NF-κB
UniProt ID	[P18510](https://www.uniprot.org/uniprot/P18510)
Ensembl ID	ENSG00000136689
OMIM	147679
GeneCards	IL1RN
Human Protein Atlas	IL1RN
Receptor binding	IL-1Ra binds IL-1R1 with similar affinity to IL-1α and IL-1β, but without activating downstream signaling
No signaling	The IL-1Ra/IL-1R1 complex cannot recruit the IL-1 receptor accessory protein (IL-1RAP), blocking signal transduction
Four isoforms	Generated by alternative splicing — a secreted form (sIL-1Ra) and three intracellular forms (icIL-1Ra1, icIL-1Ra2, icIL-1Ra3)
Expression regulation	Low basal expression in most tissues; strongly upregulated by IL-1β, TNF-α, and TLR ligands
Associated Diseases	Als, Inflammation
Interactions	NF-ΚB
KG Connections	33 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL1RN — Interleukin 1 Receptor Antagonist

gene · 709 words

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Pathway Diagram

graph TD
    IL1RN["IL1RN"]
    IL1RN -->|"expressed in"| Ms["Ms"]
    IL1RN -->|"expressed in"| Neuroinflammation["Neuroinflammation"]
    IL1RN -->|"expressed in"| Inflammation["Inflammation"]
    IL1RN -->|"target for"| Autoimmune["Autoimmune"]
    IL1RN -->|"target for"| Rheumatoid_Arthritis["Rheumatoid Arthritis"]
    IL1RN -->|"expressed in"| MICROGLIA["MICROGLIA"]
    IL1RN -->|"expressed in"| MIRNAS["MIRNAS"]
    INFLAMMATION["INFLAMMATION"] -->|"target for"| IL1RN

Outgoing (22)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:IL1RN	data_in	dataset_row	0.00
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
NEUROINFLAMMATION	expressed_in	gene	0.60
MMP3	expressed_in	gene	0.60
IL1R1	expressed_in	gene	0.60
SERPINA3	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
MIRNAS	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
TGFB1	associated_with	gene	0.60
IL10	associated_with	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
NF-ΚB	activates	gene	0.60
Nf-Κb	activates	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:IL1RN	data_in	dataset_row	0.00
TNF	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
IL6	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
NFKB1	associated_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IL1A	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
INFLAMMATION-RELATED GENES	associated_with	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning il1rn in their description or question text

No additional research found