protein

HUNTINGTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUNTINGTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

815Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HUNTINGTIN is a protein involved in neurodegeneration research. Key relationships include: associated with, contributes to, regulates. Associated with ALS, Aging, Als. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HUNTINGTIN
Full Name	Huntingtin (HTT)
Protein Type	Protein
Function	is a large protein encoded by the HTT gene, most famous for its role in Huntington's disease where CAG repeat expansion in the first exon leads to mutant huntingtin (mHTT).
Molecular Weight	350 kDa
Amino Acids	144 aa
Pathways	NF-κB
UniProt ID	Search UniProt
GeneCards	HUNTINGTIN
Human Protein Atlas	HUNTINGTIN
Normal range	10-35 glutamine residues
Reduced penetrance	36-39 glutamines
Full penetrance	≥40 glutamines
Anticipation	Earlier onset in subsequent generations correlates with paternal transmission[@langbehn2004]
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	RAPAMYCIN
Interactions	Actin, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, amyotrophic lateral sclerosis
KG Connections	654 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HUNTINGTIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Huntingtin (HTT)

protein · 3134 words

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Pathway Diagram

graph TD
    HUNTINGTIN["HUNTINGTIN"]
    HUNTINGTIN -->|"regulates"| BDNF["BDNF"]
    HUNTINGTIN -->|"regulates"| BDNF_synthesis["BDNF synthesis"]
    HUNTINGTIN -->|"regulates"| BDNF_transport["BDNF transport"]
    HUNTINGTIN -->|"causes"| Huntington_s_disease["Huntington's disease"]
    HUNTINGTIN -->|"expressed in"| cerebrospinal_fluid["cerebrospinal fluid"]
    HUNTINGTIN -->|"regulates"| Aging["Aging"]
    HUNTINGTIN -->|"regulates"| Alzheimer["Alzheimer"]
    HUNTINGTIN -->|"regulates"| Parkinson["Parkinson"]
    HUNTINGTIN -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    HUNTINGTIN -->|"regulates"| Stroke["Stroke"]
    HTT["HTT"] -->|"encodes"| HUNTINGTIN
    antisense_oligonucleotides["antisense oligonucleotides"] -->|"inhibits"| HUNTINGTIN
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"regulates"| HUNTINGTIN
    BCL_2["BCL-2"] -->|"regulates"| HUNTINGTIN
    STROKE["STROKE"] -->|"regulates"| HUNTINGTIN
    MITOCHONDRIA["MITOCHONDRIA"] -->|"regulates"| HUNTINGTIN
    PRESENILIN_1["PRESENILIN-1"] -->|"regulates"| HUNTINGTIN
    PRESENILIN["PRESENILIN"] -->|"regulates"| HUNTINGTIN
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| HUNTINGTIN
    EXERCISE["EXERCISE"] -->|"regulates"| HUNTINGTIN

Outgoing (495)

Target	Relation	Type	Str
BDNF synthesis	regulates	pathway	0.90
BDNF transport	regulates	pathway	0.90
BDNF	regulates	protein	0.90
BDNF	transports	gene	0.90
Tau Pathology	promotes	mechanism	0.85
Huntington's disease	implicated_in	disease	0.80
DNA damage response	regulates	process	0.80
chromatin remodeling	regulates	process	0.80
RNA processing	regulates	process	0.80
polyglutamine	aggregates_with	compound	0.80
cerebrospinal fluid	expressed_in	process	0.70
Huntington's disease	causes	disease	0.70
AUTOPHAGY	inhibits	phenotype	0.70
AUTOPHAGY	treats	phenotype	0.70
Neurodegeneration	transports	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Depression	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Huntington	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	stabilizes	disease	0.65
Huntington	protects_against	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
ALS	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Neurodegeneration	causes	disease	0.65
Als	causes	disease	0.65
Als	activates	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
PINK1	degrades	gene	0.65
Huntington	transports	disease	0.65
ALS	activates	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Ms	causes	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Huntington	regulates	disease	0.65
Huntington	causes	disease	0.65
Aging	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65

Incoming (320)

Source	Relation	Type	Str
TAU	interacts_with	protein	0.90
HTT	encodes	gene	0.70
antisense oligonucleotides	inhibits	drug	0.70
DNAJB1	causes	gene	0.65
KYNURENINE	interacts_with	phenotype	0.65
FUS	regulates	gene	0.65
HUNTINGTON'S DISEASE	encodes	disease	0.65
HUNTINGTON'S DISEASE	targets	disease	0.65
HUNTINGTON'S DISEASE	contributes_to	gene	0.60
AMYLOID-BETA	contributes_to	gene	0.60
PARKINSON'S DISEASE	contributes_to	gene	0.60
LNCRNA	therapeutic_target	gene	0.60
MITOCHONDRIA	contributes_to	gene	0.60
HUNTINGTON	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
DNA	regulates	gene	0.60
RNA	regulates	gene	0.60
DNA	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
MTORC1	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ENDOSOME	associated_with	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
HTT	expressed_in	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
MLH1	activates	gene	0.60
BDNF	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
NEURON	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
BDNF	therapeutic_target	gene	0.60
CYP46A1	therapeutic_target	gene	0.60
HUNTINGTON	causes	gene	0.60
ASTROCYTE	expressed_in	gene	0.60
HUNTINGTIN	causes	gene	0.60
HTT	expressed_in	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
SYNAPSE	therapeutic_target	gene	0.60
GSK3	inhibits	gene	0.60
GSK3	inhibits	gene	0.60
CDK2	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
HDAC4	inhibits	gene	0.60
HUNTINGTIN	interacts_with	gene	0.60
DNAJB6	interacts_with	gene	0.60
P21	inhibits	gene	0.60
CDK4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
HUNTINGTIN	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HUNTINGTIN in their description or question text

No additional research found