protein

HSP70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1182Connections

12Hypotheses

9Analyses

50Outgoing

50Incoming

1Experiments

11Debates

Summary

HSP70 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Als. Connected to 481 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HSPA1A
Full Name	Heat Shock Protein Family A (Hsp70) Member 1A/1B
Aliases	HSP70
Chromosome	6p21.33 (HSPA1A), 6p21.33 (HSPA1B)
Protein Family	Heat shock protein 70 family (HSP70 superfamily)
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cytoplasm, nucleus (stress-induced)
Molecular Weight	70 kDa
Amino Acids	640 aa
Pathways	Akt, Apoptosis, Chaperone, Complement, Epithelial-Mesenchymal Transition
UniProt ID	P0DMV8
OMIM	140100
GeneCards	HSPA1A
Human Protein Atlas	HSPA1A
Associated Diseases	Als, Alzheimer, alzheimer_disease, alzheimers, cancer
Known Drugs/Compounds	5S rRNA, 5S Rrna, aducanumab, Arimoclomol, Geranylgeranylacetone, lecanemab
Interactions	Actin, ADAM10, AIMP2-DX2, AKT, AKT1, AKT1S1
KG Connections	1167 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HSP70 — AlphaFold P0DMV8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HSP70(["HSP70"])
    Nf__b["Nf-Kappab"]
    NF__B(["NF-KappaB"])
    Inflammation["Inflammation"]
    Als["Als"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Cancer["Cancer"]
    Apoptosis["Apoptosis"]
    poly_GA_aggregates("poly-GA aggregates")
    Oxidative_Stress["Oxidative Stress"]
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    UBQLN2(["UBQLN2"])
    TIA1(["TIA1"])
    PI3K(["PI3K"])

    HSP70 -->|"regulates"| Nf__b
    NF__B -->|"regulates"| HSP70
    HSP70 -->|"activates"| Inflammation
    HSP70 -->|"activates"| Als
    HSP70 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    HSP70 -->|"regulates"| Cancer
    HSP70 -->|"regulates"| Apoptosis
    HSP70 -->|"activates"| poly_GA_aggregates
    HSP70 -->|"therapeutic target"| Apoptosis
    HSP70 -->|"therapeutic target"| Oxidative_Stress
    HSP70 -->|"activates"| Apoptosis
    HSP70 -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS
    UBQLN2 -->|"interacts with"| HSP70
    TIA1 -.->|"inhibits"| HSP70
    PI3K -->|"regulates"| HSP70

    style HSP70 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (732)

Target	Relation	Type	Str
HSP70	encodes	protein	0.00
Cellular Homeostasis	associated_with	process	0.95
anxiety-like behavior	associated_with	unknown	0.95
sleep deprivation	associated_with	mechanism	0.95
alzheimer_disease	modulates	disease	0.95
cognitive impairment	associated_with	unknown	0.95
protein_aggregation	inhibits	mechanism	0.95
5S Rrna	binds	compound	0.95
Trna	binds	compound	0.95
Non-Coding Rna	interacts_with	compound	0.95
Non-coding RNA	binds	process	0.95
tRNA	binds	compound	0.92
5S rRNA	binds	compound	0.92
RNA Polymerase III	regulates	enzyme	0.90
Trna Gene Transcription	modulates	process	0.90
Rna Polymerase Iii	regulates	protein	0.90
Non-Coding Rna Biogenesis	involved_in	process	0.90
proteotoxic stress	biomarker_for	unknown	0.90
ischemic_injury	associated_with	unknown	0.90
cerebral ischemia-reperfusion injury	protects_against	unknown	0.90
neuronal_survival	associated_with	unknown	0.90
Cancer	associated_with	disease	0.90
Neurodegeneration	associated_with	disease	0.90
Protein Folding	involved_in	process	0.90
AIMP2-DX2	regulates	protein	0.90
tRNA Gene Transcription	upregulates	process	0.88
TDP-43 aggregation	inhibits	mechanism	0.85
Huntington's disease	suppresses	unknown	0.85
Protein Homeostasis	involved_in	process	0.85
necrosis	inhibits	unknown	0.85
Sleep	associated_with	process	0.85
SIAH1	inhibits	protein	0.85
AIMP2-DX2	co_expressed_with	protein	0.85
alpha_synuclein_aggregation	degrades	mechanism	0.85
oxidative_stress	biomarker_for	phenotype	0.85
mitochondrial_dysfunction	modulates	mechanism	0.85
Sleep Disorders	targets	disease	0.85
Apoptosis	regulates	process	0.80
Tumor Progression	associated_with	process	0.80
Cell Transformation	modulates	process	0.80
CMA	associated_with	process	0.80
UBQLN2	interacts_with	gene	0.80
alpha_synuclein_aggregation	inhibits	mechanism	0.80
small molecule chaperones	associated_with	drug	0.80
TDP-43_aggregation	prevents	phenotype	0.80
cell damage	associated_with	unknown	0.80
GCase	interacts_with	protein	0.80
Nf-Κb	regulates	pathway	0.80
protein_folding_pathway	participates_in	pathway	0.80
oxidative_stress	mediates	phenotype	0.78

Incoming (450)

Source	Relation	Type	Str
HSP70	encodes	gene	0.00
AIMP2-DX2	interacts_with	protein	0.95
TSG-6	upregulates	unknown	0.95
stress granule formation	associated_with	mechanism	0.95
DNAJB6	binds	protein	0.95
DNAJB6	interacts_with	protein	0.95
DNAJB6	activates	protein	0.90
Copper	upregulates	compound	0.85
GCase	interacts_with	protein	0.85
HSP40	activates	gene	0.85
small molecule chaperones	activates	drug	0.85
BHB	upregulates	compound	0.80
APE2	binds	gene	0.80
Allosteric Mechanisms	regulates	mechanism	0.80
Arimoclomol	activates	drug	0.80
Geranylgeranylacetone	activates	drug	0.80
small_molecule_chaperones	activates	unknown	0.80
HSPA1A	encodes	gene	0.80
NF-ΚB	regulates	gene	0.80
DNAJB1	activates	gene	0.75
small molecule chaperones	associated_with	drug	0.75
UBQLN2	interacts_with	gene	0.70
PI3K	regulates	gene	0.70
TIA1	inhibits	gene	0.70
HIF	regulates	gene	0.70
APOPTOSIS	regulates	gene	0.70
CANCER	regulates	gene	0.70
small_molecule_chaperones	associated_with	unknown	0.70
HSP40	associated_with	gene	0.65
APOE4	activates	gene	0.65
APOE4	regulates	gene	0.65
HSP40	interacts_with	gene	0.65
GDNF	protects_against	gene	0.65
DNAJA1	activates	gene	0.65
SQSTM1	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
ALS	associated_with	gene	0.60
RIPK1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Exposed amyloidogenic segments (β-sheet propensity residues)	0.761	protein biochemistry	Do chaperones selectively recognize path
H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Rever	0.577	neurodegeneration	How do pathological stress granules tran
Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across
BAG3-Mediated Hsp70 Substrate Redistribution	0.540	neurodegeneration	How does controlled lysosomal membrane p

APOE4 Structural Remodeling via HSP70 Chaperone Enhancement	0.486	molecular biology	Is APOE4's reduced lipid binding pathoge
Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric I	0.481	protein folding	Can chaperone enhancement approaches ove
Hsp70 cochaperone BAG3-mediated Autophagy Activation for Syn	0.459	proteomics	Quantitative proteomics of the aging syn
HSP70/HSP40 Chaperone Complex Secretion	0.380	neurodegeneration	Which specific factors in conditioned me
Amyloidogenic segments undergo conformational templating by	0.000	protein biochemistry	Do chaperones selectively recognize path
HSP70 recognition of exposed β-sheet segments triggers CHIP-	0.000	protein biochemistry	Do chaperones selectively recognize path
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.000	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (9)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 16 hypotheses Top: 0.559

Do chaperones selectively recognize pathological vs physiological protein confor

protein biochemistry | 2026-04-10 | 14 hypotheses Top: 0.761

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Epigenetic clocks and biological aging in neurodegeneration

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.710

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Nation-wide NGS-based genetic screening of LGMD patients in US	exploratory	Limb-girdle muscular dystrophy	0.950	0.00	Human patients	proposed	N/A

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702]	Resnick SJ, Qamar S, Krishna P, Korobeyn	Nature communications	2025
Extracellular chaperone networks and the export of J-domain proteins. [PMID:36581212]	Braun JEA	The Journal of biological chem	2023
DNAJB6 mutants display toxic gain of function through unregulated interaction wi [PMID:37923706]	Abayev-Avraham M, Salzberg Y, Gliksberg	Nature communications	2023
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuc [PMID:36302971]	Kuiper EFE, Gallardo P, Bergsma T, Mari	Nature cell biology	2022
A 20-year Clinical and Genetic Neuromuscular Cohort Analysis in Lebanon: An Inte [PMID:34602496]	Megarbane A, Bizzari S, Deepthi A, Sabba	Journal of neuromuscular disea	2022
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkin [PMID:34390836]	["Arkan S", "Ljungberg M", "Kirik D", "H	Neurobiology of disease	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021
Panorama of the distal myopathies. [PMID:33458580]	Savarese M, Sarparanta J, Vihola A, Jons	Acta myologica : myopathies an	2020
Functional characterization of 84 PALB2 variants of uncertain significance. [PMID:31636395]	Wiltshire T, Ducy M, Foo TK, Hu C, Lee K	Genetics in medicine : officia	2020
DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. [PMID:32268123]	["Thiruvalluvan A", "de Mattos E", "Brun	Molecular cell	2020
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment [PMID:30737131]	Merlini M, Rafalski VA, Rios Coronado PE	Neuron	2019
Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 [PMID:30564623]	Nallamilli BRR, Chakravorty S, Kesari A,	Annals of clinical and transla	2018
Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer. [PMID:27276715]	Meng E, Shevde LA, Samant RS	Oncotarget	2016

Debates (11)

Multi-agent debates referencing this entity

The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems ca

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

closed · Rounds: 6 · Score: 0.84 · 2026-04-12

TDP-43 phase separation therapeutics for ALS-FTD

closed · Rounds: 4 · Score: 0.95 · 2026-04-11

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Epigenetic clocks and biological aging in neurodegeneration

closed · Rounds: 4 · Score: 0.93 · 2026-04-06

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

What are the mechanisms underlying tdp-43 phase separation therapeutics for als-

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning HSP70 in their description or question text

HSP70

Understanding Entity Pages

Summary

Wiki Pages (8)

HSP70 (Heat Shock Protein 70 / HSPA1A)

Alzheimer's Disease HSP70/HSP90 Chaperone and Protein Folding Therapy Companies

HSP70/HSP90 Modulators

HSP70 Protein

HSP70 Inducer Therapies for Neurodegeneration

HSP70 Inducer Therapies for Neurodegeneration

HSP70 Gene

HSP70 Inducer Therapies

Pathway Diagram

Outgoing (732)

Incoming (450)

Targeting Hypotheses (12)

Mentioning Analyses (9)

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

Do chaperones selectively recognize pathological vs physiological protein confor

Tau propagation mechanisms and therapeutic interception points

Epigenetic clocks and biological aging in neurodegeneration

Digital biomarkers and AI-driven early detection of neurodegeneration

APOE4 structural biology and therapeutic targeting strategies

TDP-43 phase separation therapeutics for ALS-FTD

TDP-43 phase separation therapeutics for ALS-FTD

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (1)

Related Papers (16)

Debates (11)

The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems ca

How does synaptic protein turnover change with age and neurodegeneration, and wh

Investigate prion-like spreading of tau pathology through connected brain region

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

TDP-43 phase separation therapeutics for ALS-FTD

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

Epigenetic clocks and biological aging in neurodegeneration

Tau propagation mechanisms and therapeutic interception points

What are the mechanisms underlying tdp-43 phase separation therapeutics for als-

Related Research

APOE4 Structural Remodeling via HSP70 Chaperone Enhancement Strategy

Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric Imbalance in Advanced

Hsp70 cochaperone BAG3-mediated Autophagy Activation for Synaptic Protein Qualit

HSP70/HSP40 Chaperone Complex Secretion

Amyloidogenic segments undergo conformational templating by HSP90-HSP70 heteroco

HSP70 recognition of exposed β-sheet segments triggers CHIP-mediated selective d

Exposed amyloidogenic segments trigger CHIP-mediated oligomer-selective ubiquiti