Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP-43_aggregation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | contributes_to | mechanism | 0.78 |
| neurodegeneration | contributes_to | disease | 0.75 |
| glymphatic_clearance | associated_with | mechanism | 0.75 |
| mitochondrial_dysfunction | associated_with | mechanism | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP70 | prevents | protein | 0.80 |
| glymphatic_clearance | mediates | mechanism | 0.80 |
| TREM2_protein | correlates_with | protein | 0.75 |
| microglial_activation | associated_with | mechanism | 0.75 |
| oxidative_stress | contributes_to | phenotype | 0.75 |
| neuroinflammation | associated_with | mechanism | 0.75 |
| AQP4 | associated_with | protein | 0.75 |
| HSP70 | modulates | protein | 0.70 |
| APOE4 | contributes_to | protein | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin- | 0.600 | neurodegeneration | What are the neuron-specific effects of |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning TDP-43_aggregation in their description or question text
No additional research found