Contents

HSP70 Gene

🧬 Gene Info

Gene Symbol	HSPA1A
Full Name	Heat Shock Protein Family A (Hsp70) Member 1A/1B
Aliases	HSP70
Chromosome	6p21.33 (HSPA1A), 6p21.33 (HSPA1B)
Protein Family	Heat shock protein 70 family (HSP70 superfamily)
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cytoplasm, nucleus (stress-induced)
Molecular Weight	70 kDa
Amino Acids	640 aa
Pathways	Akt, Apoptosis, Chaperone, Complement, Epithelial-Mesenchymal Transition
UniProt ID	P0DMV8
OMIM	140100
GeneCards	HSPA1A
Human Protein Atlas	HSPA1A
Associated Diseases	Als, Alzheimer, cancer, dementia
Known Drugs/Compounds	5S rRNA, 5S Rrna, aducanumab, lecanemab, Non-Coding Rna, rapamycin
Interactions	Actin, ADAM10, AIMP2-DX2, AKT, AKT1, AKT1S1
KG Connections	1124 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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Knowledge Graph

HSPA1A expressed_in HSP70

HSPA1A associated_with HSP70

OPTN interacts_with HSP70

CASP3 interacts_with HSP70

AKT1 interacts_with HSP70

CALCOCO2 interacts_with HSP70

CGAS interacts_with HSP70

CFTR interacts_with HSP70

SQSTM1 interacts_with HSP70

RPS6KB1 interacts_with HSP70