concept

TDP-43 AGGREGATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

1Hypotheses

1Analyses

10Outgoing

20Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	TDP-43 AGGREGATION

Pathway Diagram

graph TD
    TDP_43_AGGREGATION["TDP-43 AGGREGATION"]
    TDP_43_AGGREGATION -->|"causes"| Neurodegeneration["Neurodegeneration"]
    TDP_43_AGGREGATION -->|"contributes to"| Als_Pathology["Als Pathology"]
    TDP_43_AGGREGATION -->|"contributes to"| Ftd_Pathology["Ftd Pathology"]
    TDP_43_AGGREGATION -->|"mediates"| TDP_43_Loss_Of_Function["TDP-43 Loss Of Function"]
    TDP_43_AGGREGATION -.biomarker for.-> Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TDP_43_AGGREGATION -->|"interacts"| TDP_43_Mislocalization["TDP-43 Mislocalization"]
    p38__MAPK_inhibition["p38alpha MAPK inhibition"] -->|"reduces"| TDP_43_AGGREGATION
    oxidative_stress["oxidative stress"] -->|"promotes"| TDP_43_AGGREGATION
    SUMO2_3_conjugation["SUMO2/3 conjugation"] -.protects against.-> TDP_43_AGGREGATION
    TARDBP["TARDBP"] -->|"involved_in"| TDP_43_AGGREGATION
    cAMP_PKA_Signaling["cAMP/PKA Signaling"] -->|"modulates"| TDP_43_AGGREGATION
    Loss_Of_ASRGL1["Loss Of ASRGL1"] -->|"causes"| TDP_43_AGGREGATION
    Oxidative_Stress["Oxidative Stress"] -->|"activates"| TDP_43_AGGREGATION
    ASRGL1["ASRGL1"] -->|"inhibits"| TDP_43_AGGREGATION

Outgoing (10)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.98
Neurodegeneration	causes	phenotype	0.95
Als Pathology	contributes_to	phenotype	0.93
Ftd Pathology	contributes_to	phenotype	0.93
TDP-43 Loss Of Function	mediates	phenotype	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
TDP-43 Mislocalization	interacts_with	process	0.85
Neuronal Lipid Profile Alterations	correlates_with	mechanism	0.75
Ferroptosis markers	precedes	biomarker	0.70
neuronal viability	inhibits	process	0.70

Incoming (20)

Source	Relation	Type	Str
oxidative stress	promotes	process	1.00
p38α MAPK inhibition	reduces	process	1.00
SUMO2/3 conjugation	protects_against	process	1.00
TARDBP	involved_in	protein	0.98
cAMP/PKA Signaling	modulates	pathway	0.95
Loss Of ASRGL1	causes	mechanism	0.95
ASRGL1	inhibits	gene	0.90
C9orf72 repeat expansion	causes	gene	0.90
Phase Separation	contributes_to	process	0.90
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.90
Oxidative Stress	activates	process	0.90
Phosphatidylserine	promotes	compound	0.88
Cardiolipin	promotes	compound	0.88
TDP-43 S409/S410 Phosphorylation	associated_with	process	0.85
Autophagy-Lysosome Pathway	involved_in	pathway	0.85
Oxidative Stress	exacerbates	process	0.85
NUFIP2	contributes_to	protein	0.80
oxidative stress	causes	process	0.80
P38	enhances	gene	0.70
misfolded PrP	induces	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-	0.600	neurodegeneration	What are the neuron-specific effects of

Mentioning Analyses (1)

Scientific analyses that reference this entity

Is ferroptosis the primary driver of motor neuron death in ALS or an epiphenomen

neurodegeneration | 2026-04-18 | 4 hypotheses Top: 0.538

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted compelling correlative evidence for ferroptosis markers i

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning TDP-43 AGGREGATION in their description or question text

No additional research found