concept

OXIDATIVE_STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE_STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

6Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

OXIDATIVE_STRESS is a concept in neurodegeneration research. Key relationships include: causes, inhibits, activates. Associated with CVD, NEURODEGENERATION, PARKINSON_DISEASE. Connected to 46 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OXIDATIVE_STRESS
Key Genes/Proteins	AKT, ASK1, BAK1, BAX, BID, CA2
Related Diseases	CARDIAC_AGING, CELLULAR_SENESCENCE, CVD
Related Pathways	AUTOPHAGY, CA2_HOMEOSTASIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Oxidative Stress in Neurodegeneration

mechanism · 3216 words

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Pathway Diagram

graph TD
    OXIDATIVE_STRESS["OXIDATIVE_STRESS"]
    OXIDATIVE_STRESS -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    OXIDATIVE_STRESS -->|"causes"| hemolysis["hemolysis"]
    OXIDATIVE_STRESS -->|"causes"| OxPCs["OxPCs"]
    OXIDATIVE_STRESS -->|"inhibits"| CA2_HOMEOSTASIS["CA2_HOMEOSTASIS"]
    OXIDATIVE_STRESS -->|"causes"| STRESS_GRANULES["STRESS_GRANULES"]
    OXIDATIVE_STRESS -->|"causes"| DNA_DAMAGE["DNA_DAMAGE"]
    OXIDATIVE_STRESS -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
    OXIDATIVE_STRESS -->|"regulates"| CA2["CA2"]
    OXIDATIVE_STRESS -->|"regulates"| calcium["calcium"]
    OXIDATIVE_STRESS -->|"causes"| intestinal_barrier["intestinal_barrier"]
    NRF2["NRF2"] -->|"regulates"| OXIDATIVE_STRESS
    HSPA1A["HSPA1A"] -->|"inhibits"| OXIDATIVE_STRESS
    hydrogen_peroxide["hydrogen_peroxide"] -->|"causes"| OXIDATIVE_STRESS
    ROS["ROS"] -->|"causes"| OXIDATIVE_STRESS
    SIRT1["SIRT1"] -->|"inhibits"| OXIDATIVE_STRESS
    SIRT3["SIRT3"] -->|"inhibits"| OXIDATIVE_STRESS
    METHYLENE_BLUE["METHYLENE_BLUE"] -->|"inhibits"| OXIDATIVE_STRESS
    curcumin["curcumin"] -->|"inhibits"| OXIDATIVE_STRESS
    GPS["GPS"] -->|"inhibits"| OXIDATIVE_STRESS

Outgoing (72)

Target	Relation	Type	Str
sepsis-associated encephalopathy	contributes_to	unknown	0.95
alzheimers	implicated_in	disease	0.95
Parkinson's disease	implicated_in	unknown	0.95
protein aggregation	causes	mechanism	0.90
mitochondrial_dysfunction	associated_with	mechanism	0.90
neuroinflammation	causes	mechanism	0.90
microglial_activation	causes	mechanism	0.90
ASK1	activates	protein	0.90
APOPTOSIS	associated_with	process	0.90
NEURODEGENERATION	activates	disease	0.87
mitochondrial_dysfunction	modulates	mechanism	0.85
Parkinson's disease	involved_in	unknown	0.85
neurological dysfunction	causes	unknown	0.85
alzheimer_disease	involved_in	disease	0.85
protein aggregation	contributes_to	mechanism	0.85
neuroinflammation	associated_with	mechanism	0.85
lysophosphatidylcholine	correlates_with	unknown	0.85
neuronal death	contributes_to	unknown	0.85
lysophosphatidylethanolamine	correlates_with	unknown	0.85
microglial_activation	associated_with	mechanism	0.80
NEURON	causes	cell_type	0.80
mitochondrial_transfer	inhibits	mechanism	0.80
mitochondrial_dysfunction	causes	mechanism	0.80
alzheimers	contributes_to	disease	0.80
cognitive dysfunction	causes	unknown	0.80
mitochondrial_dysfunction	contributes_to	mechanism	0.80
Parkinson's disease	contributes_to	unknown	0.80
microglial_activation	activates	mechanism	0.75
microglial_activation	contributes_to	mechanism	0.75
alpha_synuclein_aggregation	contributes_to	mechanism	0.75
alzheimer_disease	contributes_to	disease	0.75
TDP-43_aggregation	contributes_to	phenotype	0.75
ischemic_injury	contributes_to	unknown	0.75
neuroinflammation	contributes_to	mechanism	0.75
alzheimer_disease	associated_with	disease	0.75
glymphatic_clearance	associated_with	mechanism	0.75
blood-brain barrier permeability	associated_with	unknown	0.75
alzheimers	associated_with	disease	0.75
Parkinson's disease	associated_with	unknown	0.75
aging	associated_with	unknown	0.75
hemolysis	causes	phenotype	0.72
OxPCs	causes	protein	0.72
CA2	regulates	protein	0.72
CA2_HOMEOSTASIS	inhibits	pathway	0.72
STRESS_GRANULES	causes	phenotype	0.72
DNA_DAMAGE	causes	phenotype	0.72
FERROPTOSIS	causes	phenotype	0.72
glymphatic_clearance	inhibits	mechanism	0.70
GCase	inhibits	protein	0.70
protein_aggregation	associated_with	mechanism	0.70

Incoming (81)

Source	Relation	Type	Str
iron mismanagement	causes	unknown	0.95
lipid_droplet_biogenesis	causes	pathway	0.90
microglial_activation	causes	mechanism	0.90
iron	causes	unknown	0.90
iron accumulation	causes	mechanism	0.90
Cytokines	causes	protein	0.90
loss of iron homeostasis	associated_with	unknown	0.90
HSP70	biomarker_for	protein	0.85
intermittent_fasting	modulates	unknown	0.85
alzheimer_disease	associated_with	disease	0.85
AMPK	inhibits	unknown	0.85
mitochondrial_transfer	contributes_to	mechanism	0.85
GCase	causes	protein	0.85
TNF	associated_with	protein	0.85
HK2	modulates	protein	0.85
mitochondrial_transfer	modulates	mechanism	0.82
microglial_activation	increases_risk	mechanism	0.80
GCase	associated_with	protein	0.80
neurodegeneration	associated_with	disease	0.80
protein aggregation	associated_with	mechanism	0.80
adolescent alcohol consumption	causes	unknown	0.80
insulin_resistance	contributes_to	unknown	0.80
beta-amyloid	causes	unknown	0.80
APOE4	contributes_to	protein	0.80
microglial_activation	contributes_to	mechanism	0.80
sleep_deprivation	causes	phenotype	0.80
NNMT	causes	gene	0.80
NRF2	regulates	protein	0.79
HSP70	mediates	protein	0.78
Edaravone	treats	drug	0.78
GPR32	modulates	protein	0.78
ferroptosis	associated_with	mechanism	0.75
GCase	modulates	protein	0.75
Tau	associated_with	unknown	0.75
TREM1	modulates	unknown	0.75
mitochondrial_transfer	associated_with	mechanism	0.75
HK2	associated_with	protein	0.75
APOE4	associated_with	protein	0.75
AKT	involved_in	gene	0.75
microglial_activation	mediates	mechanism	0.75
PI3K	involved_in	gene	0.75
SIRT3	inhibits	gene	0.72
hydrogen_peroxide	causes	drug	0.72
G6PD_deficiency	associated_with	disease	0.72
ROS	causes	phenotype	0.72
SIRT1	inhibits	gene	0.72
HSPA1A	inhibits	gene	0.72
AQP4	associated_with	protein	0.72
FOXO1	modulates	gene	0.70
TFEB	modulates	protein	0.70

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Unde	0.700	neurodegeneration	Investigate mechanisms of epigenetic rep
NRF2-Mediated Proteostatic Convergence: Shared Oxidative Str	0.700	neurodegeneration	-
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
NRF2 Activation to Counteract Oxidative Stress from RGS6 Def	0.518	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
XOR+ stress-responsive astrocytes represent a novel AD-assoc	0.380	Alzheimer's disease	-

Astrocyte-specific autophagy deficiency induces NADPH oxidas	0.380	ALS	How do non-cell autonomous effects of au

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
In midlife, lower Aβ42:Aβ40 ratio was associated with increased risk o	clinical	Alzheimer's disease	0.500	0.00	human	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying mitochondrial transfer between astrocytes and

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning OXIDATIVE_STRESS in their description or question text

Astrocyte-specific autophagy deficiency induces NADPH oxidase-mediated oxidative

Score: 0.380 · ALS · 2026-04-27

We hypothesize that autophagy dysfunction specifically in astrocytes induces motor neuron toxicity through impaired mito