| Gene Symbol | ent-gene-95937963 |
| HSPA1A/HSP70-1 | Inducible stress response chaperone, primary target for pharmacological activation |
| HSPA8/Hsc70 | Constitutively expressed chaperone involved in protein folding and autophagy |
| BiP/GRP78 | ER-resident HSP70 involved in unfolded protein response |
| HSF1 activators | Direct activation of heat shock factor 1 to drive HSP70 transcription |
| Geranylgeranylacetone (GGA) | FDA-approved HSP70 inducer used for gastric ulcers, being repurposed for neurodegeneration |
| Curcumin | Polyphenol that activates HSF1 and upregulates HSP70 |
| Resveratrol | SIRT1 activator that enhances HSP70 expression via AMPK pathway |
| Sulforaphane | NRF2 activator with secondary HSP70 induction |
| Tat-HSP70 fusion peptides | Cell-penetrating peptides that deliver functional HSP70 domains |
| Boss-C70 | Engineered co-chaperone domain peptides that enhance HSP70 activity |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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