| Gene Symbol | GSK |
| Full Name | 3β Protein |
| Aliases | GSK3BETAPROTEIN |
| Function | Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase originally identified for its role in glycogen metabolism. |
| GeneCards | GSK |
| Human Protein Atlas | GSK |
| N-terminal domain | Contains inhibitory phosphorylation site (Ser9) |
| Kinase domain (residues 35-350) | ATP-binding pocket, substrate-binding groove |
| Activation loop | Requires priming of substrates |
| C-terminal tail | Regulatory interactions |
| Ser9 phosphorylation | By AKT, PKA, PKB → Inhibitory, blocks substrate access |
| Tyr216 phosphorylation | Autophosphorylation → Activating |
| Substrate priming | Most substrates require pre-phosphorylation at +4 position |
| [APP](/entities/app-protein) processing | GSK-3β enhances γ-secretase activity |
| Neuroinflammation | Activates NLRP3 inflammasome via NF-κB |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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