protein 2,976 words KG: GSK3BETA
Contents

GSK-3β

🔬 Protein Info
Gene SymbolGSK
Full Name3β (Glycogen Synthase Kinase 3 Beta)
AliasesGSK3BETA
FunctionGlycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase originally identified for its role in glycogen metabolism.
Subcellular LocalizationThe crystal structure of GSK-3β (PDB: 1H8F) reveals a bi-lobed kinase fold typical of eukaryotic protein kinases, with t
GeneCardsGSK
Human Protein AtlasGSK
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (20)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.87
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
APOE-Dependent Autophagy Restoration
Score: 0.86
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (11)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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