concept

LOXL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOXL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

28Incoming

0Experiments

0Debates

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💡 Concept Info

Name	LOXL3
Key Genes/Proteins	AND, App, CANCER, Collagen, Egfr
Related Diseases	Als, ALS, Cancer
Related Pathways	Catalytic Motifs

Pathway Diagram

graph TD
    LOXL3["LOXL3"]
    LOXL3 -->|"involved_in"| Cancer_Progression["Cancer Progression"]
    LOXL3 -->|"involved_in"| Extracellular_Matrix_Remodelin["Extracellular Matrix Remodeling"]
    LOXL3 -->|"involved_in"| Extracellular_Matrix["Extracellular Matrix"]
    LOXL3 -->|"involved_in"| Tissue_Homeostasis["Tissue Homeostasis"]
    LOXL3 -->|"regulates"| Innate_Immunity["Innate Immunity"]
    LOXL3 -->|"regulates"| Adaptive_Immunity["Adaptive Immunity"]
    LOXL3 -->|"expressed in"| Endostyle["Endostyle"]
    LOXL3 -->|"expressed in"| Liver["Liver"]
    LR_LOXL3["LR.LOXL3"] -->|"interacts"| LOXL3
    GENES["GENES"] -->|"target for"| LOXL3
    LOXL1_4["LOXL1-4"] -->|"expressed in"| LOXL3
    LOX["LOX"] -->|"inhibits"| LOXL3
    LOXL2["LOXL2"] -->|"expressed in"| LOXL3
    RNA["RNA"] -->|"expressed in"| LOXL3
    AND["AND"] -->|"inhibits"| LOXL3

Outgoing (73)

Target	Relation	Type	Str
Cancer Progression	promotes	process	0.95
Extracellular Matrix	involved_in	process	0.95
Extracellular Matrix Remodeling	involved_in	process	0.95
Cancer Progression	involved_in	process	0.95
Tissue Homeostasis	involved_in	process	0.92
Glioma	associated_with	disease	0.92
Adaptive Immunity	regulates	process	0.90
Innate Immunity	regulates	process	0.90
Endostyle	expressed_in	cell_type	0.90
Liver	expressed_in	cell_type	0.90
Vertebrate Immunity	involved_in	process	0.88
Glycolipid Metabolism	regulates	process	0.85
Immune-Metabolic Homeostasis	associated_with	process	0.85
Catalytic Motifs	associated_with	mechanism	0.85
Ecm Remodeling	involved_in	process	0.85
glycolipid metabolism	modulates	pathway	0.85
Phytohemagglutinin	upregulates	compound	0.85
Lipopolysaccharide	upregulates	compound	0.85
Metabolism	involved_in	process	0.82
Immunity	regulates	biological_process	0.80
PHA	modulates	compound	0.80
tumor progression	promotes	process	0.80
LOX	interacts_with	gene	0.80
PHA	upregulates	compound	0.80
LOXL1	interacts_with	gene	0.75
ALS	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Als	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	implicated_in	disease	0.65
Ms	therapeutic_target	disease	0.65
LOXL2	therapeutic_target	gene	0.60
LOXL1-4	therapeutic_target	gene	0.60
LOX	regulates	gene	0.60
LOXL1	associated_with	gene	0.60
LR.LOXL3	implicated_in	gene	0.60
AND	regulates	gene	0.60
LOX/LOXL1-4	associated_with	gene	0.60
LOXL1-4	associated_with	gene	0.60
Lipid Metabolism	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Macrophage	inhibits	cell_type	0.60
Epithelial	therapeutic_target	cell_type	0.60
T Cell	therapeutic_target	cell_type	0.60
Egfr	therapeutic_target	protein	0.60
Vegfr	therapeutic_target	protein	0.60
Collagen	therapeutic_target	protein	0.60
CANCER	inhibits	gene	0.60
Laminin	therapeutic_target	protein	0.60

Incoming (28)

Source	Relation	Type	Str
LR.LOXL3	interacts_with	gene	0.85
GENES	therapeutic_target	gene	0.60
LOXL1-4	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
LOX	inhibits	gene	0.60
LOXL2	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	inhibits	gene	0.60
LOX/LOXL1-4	expressed_in	gene	0.60
LOXL1-4	stabilizes	gene	0.60
LOX	regulates	gene	0.60
AND	regulates	gene	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
LOX/LOXL1-4	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
LOX/LOXL1-4	associated_with	gene	0.60
LOX	associated_with	gene	0.60
LOXL1	associated_with	gene	0.60
LOX	expressed_in	gene	0.60
GBM	co_expressed_with	gene	0.60
LOX	co_expressed_with	gene	0.60
LOXL1	co_expressed_with	gene	0.60
LOXL1	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
LOXL1	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOXL2	associated_with	gene	0.55
LOXL2	inhibits	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LOXL3 in their description or question text

No additional research found