| Gene Symbol | LGI2 |
| Full Name | Leucine-Rich Glioma Inactivated 2 |
| Chromosome | 4p15.2 |
| Function | is a secreted neuronal protein that belongs to the LGI family of leucine-rich repeat (LRR) domain-containing proteins. |
| Primary Expression | the brain, particularly in the hippocampus and cerebral cortex |
| Subcellular Localization | presynaptic terminals, where it may function in axonal guidance and presynaptic organization [Citation 6] |
| Amino Acids | 509 aa |
| Exons | 10 |
| GeneCards | LGI2 |
| Human Protein Atlas | LGI2 |
| Leucine-rich repeats | 14 LRR motifs forming a curved solenoid structure |
| EGF domains | Three EGF-like repeats, two of which bind calcium |
| Disulfide bonds | Multiple cysteine residues stabilizing domain interactions |
| N-linked glycosylation | Conserved glycosylation sites in the LRR domain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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