protein

HTR6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

5Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for htr6 Protein

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🔬 Protein Info

Gene Symbol	HTR6
Aliases	5-Hydroxytryptamine Receptor 6
Chromosome	1p35.3
Function	encodes a 440-amino acid protein.
Primary Expression	the central nervous system
Molecular Weight	50 kDa
Amino Acids	440 aa
Ensembl ID	ENSG00000158708
GeneCards	HTR6
Human Protein Atlas	HTR6
Basal ganglia	striatum
MAPK/ERK pathway	cAMP can activate Rap1 → B-Raf → MEK → ERK
PI3K/Akt pathway	Cross-talk with neurotrophic signaling
Calcium mobilization	Indirect effects on calcium signaling through PKA
Associated Diseases	Bipolar
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR6 Gene — 5-Hydroxytryptamine Receptor 6

gene · 1242 words

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Pathway Diagram

graph TD
    HTR6["HTR6"]
    Bipolar["Bipolar"]
    GENES["GENES"]
    FURIN["FURIN"]
    neurodegeneration["neurodegeneration"]

    HTR6 -->|"associated with"| Bipolar
    HTR6 -->|"associated with"| GENES
    HTR6 -->|"associated with"| FURIN
    HTR6 -->|"implicated in"| neurodegeneration

    style HTR6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Bipolar fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style GENES fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style FURIN fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HTR6	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Bipolar	associated_with	disease	0.65
GENES	associated_with	gene	0.60
FURIN	associated_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HTR6	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR6 in their description or question text

No additional research found