Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lipid_peroxidation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ferroptosis | causes | phenotype | 1.00 |
| FERROPTOSIS | causes | phenotype | 0.87 |
| FERROPTOSIS | regulates | phenotype | 0.72 |
| FERROPTOSIS | activates | phenotype | 0.72 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ACSL4 | activates | gene | 0.72 |
| ROS | causes | drug | 0.72 |
| LPCAT3 | activates | gene | 0.72 |
| ALOX | activates | gene | 0.72 |
| ROS | causes | phenotype | 0.72 |
| POR | activates | gene | 0.64 |
| FERROPTOSIS | regulates | phenotype | 0.64 |
| ferroptosis | regulates | pathway | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Iron-driven lipid peroxidation and GPX4 failure create a fer | 0.750 | neurodegeneration | What mechanisms drive the self-amplifyin |
| Senescence-Induced Lipid Peroxidation Spreading | 0.730 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $180,000 |
| Ferroptosis Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Iron Dyshomeostasis in MSA Pathogenesis Experiment | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Peroxisomal Dysfunction Validation in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Regulated Necrosis Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759] | Mao P, Wang Z, Duan J, Dong P, Yuan C, L | J Agric Food Chem | 2025 | 1 |
| Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591] | Luo Y, Long M, Wu X, Zeng L | Front Immunol | 2025 | 1 |
| Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283] | Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh | Biochem Pharmacol | 2024 | 1 |
| Discovery of a glycosylated colchicine derivative as a neuroprotective agent for [PMID:41455281] | ["Jash M", "Gupta S", "Garg S", "Khan J" | European journal of medicinal | 2026 | 0 |
| The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves ca [PMID:41671579] | Wang J, Li CM, Yang B, Tantai RN, Guo HX | British journal of pharmacolog | 2026 | 0 |
| From association to mechanism: Prenatal PFAS Co-exposures induces fetal neural t [PMID:41485332] | Chen Y, Cheng Q, Yang C, Li S, Lin H, Li | Journal of hazardous materials | 2026 | 0 |
| Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses i [PMID:41540498] | Fang F, Xu Q, Shen S, Wang S, Bao C | European journal of medical re | 2026 | 0 |
| Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis [PMID:41822239] | Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z | Food science & nutrition | 2026 | 0 |
| Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporo [PMID:41016294] | ["Hu L", "Luo M", "Zhu X", "Wang Z", "Ya | Phytomedicine : international | 2025 | 0 |
| Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614] | ["Jin H", "Xue B", "Chen X", "Ma T", "Ma | Environmental pollution (Barki | 2025 | 0 |
| Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferropt [PMID:40214929] | ["Zhang Y", "Tang Q", "Yao J", "Liu H", | Journal of neuroimmune pharmac | 2025 | 0 |
| Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-me [PMID:41080723] | ["Liu Q", "Zhang J", "Yu L", "Chen Y", " | Materials today. Bio | 2025 | 0 |
| Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradat [PMID:39503881] | ["Guo L", "Yang Y", "Ma J", "Xiao M", "C | Cell biology and toxicology | 2024 | 0 |
| Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST me [PMID:38906233] | ["Shi Y", "Xu N", "Liu B", "Ma Y", "Fu X | Free radical biology & medicin | 2024 | 0 |
| Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to D [PMID:37679058] | ["Liu C", "Wang Y", "Zeng Y", "Kang Z", | Advanced science (Weinheim, Ba | 2023 | 0 |
| In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. [PMID:35384401] | ["Ide K", "Souma T"] | Current protocols | 2022 | 0 |
| Commentary: Toward Less Traumatic, Not Just Less Invasive, Surgery [PMID:33188881] | Bremner Ross M | Seminars in Thoracic and Cardi | 2021 | 0 |
| En masse DNA Electroporation for in vivo Transcriptional Assay in Ascidian Embry [PMID:34692910] | Darras S | Bio-protocol | 2021 | 0 |
| Management of primary aldosteronism and mineralocorticoid receptor-associated hy [PMID:32424201] | ["Morimoto S", "Ichihara A"] | Hypertension research : offici | 2020 | 0 |
Multi-agent debates referencing this entity