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gene 524 words KG: DRP1
Contents

DRP1 Gene - Dynamin 1-Like Protein

🧬 Gene Info
Gene SymbolDRP1
Protein TypeEnzyme
FunctionThe DRP1 gene encodes a 736-amino acid GTPase
PathwaysApoptosis, Autophagy, Cell Cycle, Complement, Dna Methylation
Ensembl IDENSG00000141971
GeneCardsDRP1
Human Protein AtlasDRP1
Mitochondrial fissionMediates scission of mitochondrial outer membrane
GTP hydrolysisSelf-assembles into rings that hydrolyze GTP to drive membrane constriction
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsginsenoside Re, Ginsenoside Re, Mdivi-1, Palmitic Acid, propionic acid, Rg1
InteractionsABCD3, ABCG2, Actin, ADORA2A, AGING, AKT
KG Connections1691 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (43)

Adenosine-Astrocyte Metabolic Reset
Score: 0.73AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73CYP46A1 Overexpression Gene Therapy
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
pg 1/3Next →

Related Analyses (18)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archived

See Also (8)

ABCD3 Gene
gene · KG edge: interacts_withABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesADORA2A Gene
gene · KG edge: interacts_withAKT1 Gene
gene · KG edge: activatesAccelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

CAT interacts_with DRP1
OPTN interacts_with DRP1
CANX interacts_with DRP1
LGALS3 interacts_with DRP1
CALCOCO2 interacts_with DRP1
G3BP1 interacts_with DRP1
PEX3 interacts_with DRP1
SQSTM1 interacts_with DRP1
BCL2 interacts_with DRP1
LMNA interacts_with DRP1

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