concept

GJA1-20K

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GJA1-20K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

21Outgoing

6Incoming

0Experiments

0Debates

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💡 Concept Info

Name	GJA1-20K
Key Genes/Proteins	CONNEXIN 43

Pathway Diagram

graph TD
    GJA1_20K["GJA1-20K"]
    GJA1_20K -->|"involved_in"| Gap_Junction_Formation["Gap Junction Formation"]
    GJA1_20K -->|"interacts"| Connexin_43["Connexin 43"]
    GJA1_20K -->|"activates"| Mitochondrial_Fission["Mitochondrial Fission"]
    GJA1_20K -.protects against.-> Ischemic_Injury["Ischemic Injury"]
    GJA1_20K -->|"involved_in"| Mitochondrial_Transfer["Mitochondrial Transfer"]
    GJA1_20K -->|"downregulates"| Reactive_Oxygen_Species["Reactive Oxygen Species"]
    GJA1_20K -->|"upregulates"| ATP_Production["ATP Production"]
    GJA1_20K -->|"involved_in"| Mitochondrial_Dynamics["Mitochondrial Dynamics"]
    Ischemic_Preconditioning["Ischemic Preconditioning"] -->|"upregulates"| GJA1_20K
    Metabolic_Stress["Metabolic Stress"] -->|"upregulates"| GJA1_20K
    Ischemic_Stress["Ischemic Stress"] -->|"upregulates"| GJA1_20K

Outgoing (21)

Target	Relation	Type	Str
mitochondrial fission	associated_with	process	0.95
Gap Junction Formation	involved_in	process	0.95
cardiomyocyte	expressed_in	cell_type	0.95
Ischemic Injury	protects_against	disease	0.90
Gap Junction Formation	associated_with	process	0.90
Connexin 43	interacts_with	protein	0.90
Mitochondrial Fission	activates	process	0.90
GJA1	interacts_with	protein	0.90
reactive oxygen species	suppresses	compound	0.90
electrical coupling	associated_with	process	0.90
ATP Production	upregulates	process	0.85
Intercellular Mitochondrial Transfer	involved_in	process	0.85
Mitochondrial Transfer	involved_in	process	0.85
CONNEXIN 43	interacts_with	protein	0.85
Mitochondrial Transfer	involved_in	process	0.85
DRP1	associated_with	protein	0.85
Mitochondrial Dynamics	involved_in	process	0.85
Intercellular Mitochondrial Transfer	involved_in	process	0.80
mitochondrial dynamics	regulates	process	0.80
actin cytoskeleton	interacts_with	pathway	0.80
mitochondrial transfer	implicated_in	process	0.75

Incoming (6)

Source	Relation	Type	Str
GJA1	associated_with	gene	0.95
Ischemic Preconditioning	upregulates	process	0.85
ischemic preconditioning	associated_with	process	0.85
connexin 43	associated_with	protein	0.80
Metabolic Stress	upregulates	process	0.80
Ischemic Stress	upregulates	process	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GJA1-20K in their description or question text

No additional research found