| Gene Symbol | CRY1 |
| Full Name | Cryptochrome Circadian Regulator 1 |
| Chromosome | 12q24.31 |
| Function | Transcriptional Activation: CLOCK and BMAL1 proteins form a heterodimer that activates transcription of period (PER) and cryptochrome (CRY) genes |
| Primary Expression | Ubiquitous (high in brain, liver, retina) |
| Molecular Weight | 66 kDa |
| Amino Acids | 500 aa |
| Pathways | Akt, Circadian Rhythm, Lipid Metabolism, Mtor, Nf-Κb |
| UniProt ID | Q9UQL6 |
| NCBI Gene ID | 1399 |
| Ensembl ID | ENSG00000012048 |
| OMIM | 601033 |
| GeneCards | CRY1 |
| Human Protein Atlas | CRY1 |
| Photoreception | CRY1 detects blue light (~450 nm) through its FAD cofactor |
| Associated Diseases | Als, Depression, Stroke |
| Interactions | AKT, AMPK, ANXIETY, App, APP, BDNF |
| KG Connections | 214 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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