| Gene Symbol | CD33 |
| Full Name | Positive Microglia |
| Aliases | Siglec-3 |
| Chromosome | 19q13.41 |
| Function | Sialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins |
| Molecular Weight | 67 kDa |
| Amino Acids | 354 aa |
| Exons | 7 |
| Pathways | Apoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic |
| UniProt ID | [P20138](https://www.uniprot.org/uniprot/P20138) |
| GeneCards | CD33 |
| Human Protein Atlas | CD33 |
| Morphology | microglial cell (source: Cell Ontology) |
| Cell Type Specificity | Primarily expressed on microglia in the brain |
| Expression Levels | Variable expression across brain regions and disease states |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Stem Cell Therapy |
| Interactions | ABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID |
| SciDEX Hypotheses | CD33-Dependent Switch Hypothesis: CD33 Antagonism |
| KG Connections | 654 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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