Contents

CD33 Protein — Cluster of Differentiation 33 (Siglec-3)

🔬 Protein Info

Gene Symbol	CD33
Aliases	Siglec-3
Chromosome	19q13.41
Function	Sialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight	67 kDa
Amino Acids	354 aa
Exons	7
Pathways	Apoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID	[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCards	CD33
Human Protein Atlas	CD33
Sialic acid binding pocket	Formed by complementary determining regions (CDRs), with conserved arginine (R119) critical for sialic acid recognition
Ligand specificity	Prefers α2-6-linked sialic acids over α2-3-linked, distinguishing host from pathogen
Self-recognition function	Binds sialylated glycoproteins on host cells, generating an inhibitory "self" signal that prevents autoimmunity
Dimerization interface	V-type domains can mediate CD33 homodimerization
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Stem Cell Therapy
Interactions	ABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
KG Connections	657 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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