gene 2,879 words KG: CD33
Contents

CD33 — Cluster of Differentiation 33

🧬 Gene Info
Gene SymbolCD33
Full NameCluster of Differentiation 33
AliasesSiglec-3
Chromosome19q13.41
FunctionSialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight67 kDa
Amino Acids354 aa
Exons7
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCardsCD33
Human Protein AtlasCD33
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsStem Cell Therapy
InteractionsABCA7, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMYLOID
SciDEX HypothesesCD33-Dependent Switch Hypothesis: CD33 Antagonism
KG Connections654 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
SASP-Mediated Complement Cascade Amplification
Score: 0.70
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Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40

See Also (9)

ABCA7 (Redirect)
redirect · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

TYROBP interacts_with CD33
TYROBP associated_with CD33
APP interacts_with CD33
PSEN1 interacts_with CD33
CD33 interacts_with OVERVIEW
CD33 interacts_with PSEN1
CD33 inhibits BCL2
APP activates CD33
CD33 activates OVERVIEW
CD33 activates PSEN1

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