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gene 1,592 words KG: SIGLEC3
Contents

SIGLEC3 Gene (CD33)

🧬 Gene Info
Gene SymbolSIGLEC3
Chromosome19q13.41
Functionis a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family of cell surface receptors[@crocker2012].
Amino Acids382 aa
Exons7
Ensembl IDENSG00000105383
GeneCardsSIGLEC3
Human Protein AtlasSIGLEC3
Associated Diseasesneurodegeneration
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (9)

SASP-Mediated Complement Cascade Amplification
Score: 0.91TREM2-Dependent Microglial Senescence Transition
Score: 0.95CYP46A1 Overexpression Gene Therapy
Score: 0.92Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76APOE-TREM2 Interaction Modulation
Score: 0.74

Related Analyses (6)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

C1QA engages SIGLEC3
C1QA binds SIGLEC3

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