gene 2,164 words KG: ent-gene-c0eaddb4
Contents

ATG10 Gene

🧬 Gene Info
Gene SymbolATG10
Full NameAutophagy Related 10
Chromosome5q21.3
Protein TypeEnzyme
Functionencodes an E2-like conjugating enzyme that plays an essential role in the autophagy conjugation system.
Primary Expressiontissues throughout the body, with particularly important functions in neurons where autophagy is crucial for synaptic maintenance, mitochondrial quali
Molecular Weight21 kDa
Amino Acids182 aa
PathwaysAutophagy, Chaperone, Epigenetic, Mtor, Sod1
UniProt ID[Q9Y4K0](https://www.uniprot.org/uniprot/Q9Y4K0)
Ensembl IDENSG00000138107
OMIM610070
GeneCardsATG10
Human Protein AtlasATG10
Associated Diseasesneurodegeneration
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATG, ATG12, AUTOPHAGY
KG Connections153 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

APOE-Dependent Autophagy Restoration
Score: 0.88
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (8)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATF4 Gene
gene · KG edge: regulates
ATG12 — Autophagy Related 12
gene · KG edge: activates
BAG3 Gene
gene · KG edge: activates

Knowledge Graph (2 edges)

ent-gene-c0eaddb4 data_in benchmark_ot_ad_answer_key:ATG10
benchmark_ot_ad_answer_key:ATG10 data_in ent-gene-c0eaddb4

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