gene

LYST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

12Outgoing

0Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	Lysosomal Trafficking Regulator
Chromosome	1q42.1-q42.2
Protein Type	Regulatory Protein, Lysosomal Function
Function	encodes a large cytosolic protein that plays critical roles in lysosomal function, vesicle trafficking, and autophagy.
Primary Expression	virtually all tissues, with highest expression in:
Subcellular Localization	LYST is primarily localized to:
Amino Acids	801 aa
Pathways	Autophagy, Exocytosis
UniProt ID	Q99698
NCBI Gene ID	1130
Ensembl ID	ENSG00000143669
OMIM	606897
Lysosomes	Concentrated on lysosomal membranes
Late endosomes	Involved in endocytic trafficking
Cytoplasmic vesicles	Scattered vesicular pattern
Associated Diseases	neurodegeneration
KG Connections	12 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LYST — AlphaFold Q99698 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LYST Gene — Lysosomal Trafficking Regulator

gene · 1994 words

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Pathway Diagram

graph TD
    LYST["LYST"]
    Ms{"Ms"}
    LYST -->|"regulates"| Ms
    Als{"Als"}
    LYST -->|"regulates"| Als
    ATG1(["ATG1"])
    LYST -->|"regulates"| ATG1
    AND(["AND"])
    LYST -->|"regulates"| AND
    ATG5(["ATG5"])
    LYST -->|"regulates"| ATG5
    CLN5(["CLN5"])
    LYST -->|"regulates"| CLN5
    style LYST fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (12)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
ATG9	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
AND	regulates	gene	0.60
Exocytosis	regulates	pathway	0.60
MICROTUBULES	regulates	gene	0.60
ATG1	regulates	gene	0.60
ATG5	regulates	gene	0.60
CLN5	regulates	gene	0.60
CTSD	regulates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LYST in their description or question text

No additional research found