concept

HCRT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

274Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

3Experiments

1Debates

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💡 Concept Info

Name	HCRT
Key Genes/Proteins	ACE, ADORA2A, ADRA2A, AGING, ALZHEIMER
Related Diseases	Addiction, aging, Aging, Alcohol Drinking, Alcohol Use Disorder

Wiki Pages (1)

Knowledge base pages for this entity

HCRTR1

gene · 765 words

→

Pathway Diagram

graph TD
    HCRT["HCRT"]
    style HCRT fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HCRT -->|"activates"| Als["Als"]
    HCRT -->|"activates"| Ms["Ms"]
    HCRT -->|"target for"| Cardiovascular["Cardiovascular"]
    HCRT -->|"expressed in"| Aging["Aging"]
    HCRT -->|"implicated in"| neurodegeneration["neurodegeneration"]
    HCRT -->|"interacts"| HCRTR2([HCRTR2])
    HCRT -->|"interacts"| HCRTR1([HCRTR1])
    HCRT -->|"causes"| narcolepsy["narcolepsy"]
    h_6b84d8e2["h-6b84d8e2"] -->|"targets"| HCRT
    HCRTR2 -->|"regulates"| HCRT
    KCNQ2([KCNQ2]) -->|"regulates"| HCRT
    NEURON([NEURON]) -->|"expressed in"| HCRT
    AGING([AGING]) -->|"expressed in"| HCRT
    Neuropeptide_and_Endocrine_Sig["Neuropeptide and Endocrine Signaling in CBS/PSP"] -->|"references"| HCRT

Outgoing (157)

Target	Relation	Type	Str
OX1	activates	protein	0.95
OX2	activates	protein	0.95
Crf Neurons	interacts_with	cell_type	0.95
Narcolepsy Type 1	implicated_in	disease	0.95
HCRTR1	associated_with	gene	0.90
arousal regulation	mediates	process	0.90
Alcohol Drinking	regulates	phenotype	0.90
HCRTR2	associated_with	gene	0.90
Alcohol Use Disorder	implicated_in	disease	0.90
arousal state control	mediates	process	0.85
Arousal Dysfunction	regulates	phenotype	0.85
Blood Pressure Regulation	regulates	process	0.80
Hypertension	associated_with	disease	0.80
Sleep Regulation	involved_in	process	0.80
thalamus	expressed_in	brain_region	0.80
sleep disorders	associated_with	disease	0.70
neurons	associated_with	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Ms	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Obesity	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Addiction	activates	disease	0.65
Dementia	associated_with	disease	0.65
Anxiety	therapeutic_target	disease	0.65
Autoimmune	causes	disease	0.65
Addiction	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Sleep Disorder	regulates	disease	0.65
Sleep Disorder	causes	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	expressed_in	disease	0.65
Anxiety	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
neurodegeneration	associated_with	disease	0.65
Lewy Body	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Dementia	regulates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
ALS	activates	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	causes	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (117)

Source	Relation	Type	Str
h-6b84d8e2	targets	hypothesis	0.90
HCRTR1	activates	gene	0.60
RNA	associated_with	gene	0.60
CRH	causes	gene	0.60
AND	stabilizes	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
TAU	expressed_in	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ACE	interacts_with	gene	0.60
AGING	expressed_in	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
HCRTR2	associated_with	protein	0.60
NEURON	causes	gene	0.60
HCRTR2	regulates	gene	0.60
QRFP	biomarker_for	gene	0.60
ANXIETY	inhibits	gene	0.60
HCRTR1	regulates	gene	0.60
OXR1	inhibits	gene	0.60
HCRTR1	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEURON	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
SLEEP-WAKE CYCLE	associated_with	gene	0.60
AND	inhibits	gene	0.60
ANXIETY	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
GENES	regulates	gene	0.60
HCRTR2	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AND	regulates	gene	0.60
DMSO	inhibits	gene	0.60
DNA	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
KCNQ2	regulates	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AND	causes	gene	0.60
ACE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AND	activates	gene	0.60
C1Q	activates	gene	0.55
Autoimmune	causes	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
HCRT1	inhibits	gene	0.50
HCRT1	activates	gene	0.50
HCRT1	associated_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypocretin-Neurogenesis Coupling Therapy	0.688	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (1)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.763

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces [PMID:38123729]	Bandarabadi M, Li S, Aeschlimann L, Colo	Molecular psychiatry	2024	0
Fresh versus frozen embryo transfers in assisted reproduction. [PMID:33539543]	["Zaat T", "Zagers M", "Mol F", "Goddijn	The Cochrane database of syste	2021	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
Circuit interrogation in freely moving animals. [PMID:30573821]	Wallace Damian J; Kerr Jason N D	Nature methods	2019	0
Get Ready for Another HIT: Health Information Technology and Information Transpa [PMID:31058787]	Christopher M Horvat; Robert Bart	Pediatric critical care medici	2019	0
Diabetic neuropathy. [PMID:31197153]	["Feldman E", "Callaghan B", "Pop-Busui	Nature reviews. Disease primer	2019	0
Views and experiences with regard to antibiotic use of hospitalized patients in [PMID:29777924]	["Zanichelli V", "Monnier A", "Tebano G"	Clinical microbiology and infe	2019	0
[ [PMID:30543234]	["Isaac-Oliv\u00e9 K", "Ocampo-Garc\u00e	Nanoscale	2019	0
Spatial and temporal heterogeneity of mouse and human microglia at single-cell r [PMID:30760929]	["Masuda T", "Sankowski R", "Staszewski	Nature	2019	0
Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. [PMID:29425372]	Olsson M, Ärlig J, Hedner J, Blennow K,	Sleep	2018	0
Human hippocampal neurogenesis drops sharply in children to undetectable levels [PMID:29513649]	["Sorrells S", "Paredes M", "Cebrian-Sil	Nature	2018	0
A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Mod [PMID:29805100]	Borniger JC, Walker Ii WH, Surbhi, Emmer	Cell metabolism	2018	0
Environmental Surveillance of Norovirus Genogroups I and II for Sensitive Detect [PMID:28213546]	["Kazama S", "Miura T", "Masago Y", "Kon	Applied and environmental micr	2017	0
Probing the excitonic landscape of the Chlorobaculum tepidum Fenna-Matthews-Olso [PMID:28159567]	["Saer R", "Stadnytskyi V", "Magdaong N"	Biochimica et biophysica acta.	2017	0
Atmospheric pressure mass spectrometric imaging of live hippocampal tissue slice [PMID:29235455]	["Kim J", "Seo E", "Kim H", "Park J", "L	Nature communications	2017	0

Debates (1)

Multi-agent debates referencing this entity

Sleep disruption as cause and consequence of neurodegeneration

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Related Research

Hypotheses and analyses mentioning HCRT in their description or question text

No additional research found