Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IRS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | IRS2 |
| Key Genes/Proteins | AKT2, CD36, EP300, FAS, FASN, FOXO1 |
| Related Pathways | lipid metabolism |
graph TD
IRS2[IRS2]
IRS2 -->|activates| AKT2[AKT2]
IRS2 -->|regulates| Glucose_Metabolism[Glucose Metabolism]
IRS2 -->|involved_in| Glucose_Uptake[Glucose Uptake]
IRS2 -->|causes| PIK3CA[PIK3CA]
IRS2 -->|causes| USP25[USP25]
IRS2 -->|participates in| lipid_metabolism[lipid metabolism]
IRS2 -->|data_in| benchmark_ot_ad_answer_key_IRS[benchmark_ot_ad_answer_key:IRS2]
AKT2 -->|regulates| IRS2
CD36[CD36] -->|regulates| IRS2
FAS[FAS] -->|regulates| IRS2
FOXO1[FOXO1] -->|regulates| IRS2
EP300[EP300] -->|causes| IRS2
FASN[FASN] -->|causes| IRS2
INS[INS] -->|regulates| IRS2
benchmark_ot_ad_answer_key_IRS -->|data_in| IRS2| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:IRS2 | data_in | dataset_row | 0.00 |
| AKT2 | activates | gene | 0.90 |
| Glucose Metabolism | regulates | process | 0.90 |
| Glucose Uptake | involved_in | process | 0.85 |
| lipid metabolism | participates_in | pathway | 0.60 |
| PIK3CA | causes | gene | 0.60 |
| USP25 | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IRS2 in their description or question text
No additional research found