concept

SKA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SKA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SKA2
Key Genes/Proteins	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, App, AUTOPHAGY
Related Diseases	Als, ALS, Alzheimer, Alzheimer's disease, Alzheimer's Disease
Related Pathways	Autophagy, autophagy pathway

Pathway Diagram

graph TD
    SKA2["SKA2"]
    SKA2 -->|"inhibits"| Secretory_Autophagy["Secretory Autophagy"]
    SKA2 -->|"inhibits"| secretory_autophagy["secretory autophagy"]
    SKA2 -->|"inhibits"| IL_1__Release["IL-1beta Release"]
    SKA2 -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SKA2 -->|"activates"| STRESS_SIGNALING["STRESS_SIGNALING"]
    SKA2 -->|"regulates"| Inflammation["Inflammation"]
    SKA2 -->|"regulates"| Alzheimer["Alzheimer"]
    SKA2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FKBP5["FKBP5"] -->|"activates"| SKA2
    FKBP4["FKBP4"] -->|"activates"| SKA2
    GASDERMIN["GASDERMIN"] -->|"regulates"| SKA2
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| SKA2
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| SKA2
    NEUROTOXICITY["NEUROTOXICITY"] -->|"regulates"| SKA2
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| SKA2
    CYTOKINES["CYTOKINES"] -->|"regulates"| SKA2

Outgoing (68)

Target	Relation	Type	Str
Secretory Autophagy	inhibits	process	0.95
IL-1β Release	inhibits	process	0.90
secretory autophagy	inhibits	process	0.90
secretory autophagy	regulates	process	0.80
Alzheimer's Disease	risk_factor_for	disease	0.75
STRESS_SIGNALING	activates	pathway	0.68
ALS	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
GR	regulates	protein	0.64
FKBP5	interacts_with	protein	0.64
FKBP4	interacts_with	protein	0.64
NEURONS	expressed_in	cell_type	0.64
Actin	inhibits	protein	0.60
Cytokine	regulates	protein	0.60
DEPRESSION	associated_with	gene	0.60
Bdnf	associated_with	protein	0.60
AND	regulates	gene	0.60
GENES	associated_with	gene	0.60
Cell Cycle	associated_with	pathway	0.60
FKBP5	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
IL-1	inhibits	gene	0.60
Microglia	regulates	cell_type	0.60
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEUROTOXICITY	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
NLRP3	regulates	gene	0.60
FKBP5	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Neuron	activates	cell_type	0.60
MICROGLIA	regulates	gene	0.60
App	associated_with	protein	0.60
NEURODEGENERATION	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
PROINFLAMMATORY CYTOKINES	regulates	gene	0.60
FKBP4	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
NR3C1	associated_with	gene	0.60

Incoming (33)

Source	Relation	Type	Str
FKBP5	activates	gene	0.60
FKBP4	activates	gene	0.60
GENES	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
NEUROTOXICITY	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NLRP3	regulates	gene	0.60
PROINFLAMMATORY CYTOKINES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HSP90	regulates	gene	0.60
SNAP29	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
STX4	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
GASDERMIN	regulates	gene	0.60
IL-1	inhibits	gene	0.60
FKBP5	regulates	gene	0.60
FKBP5	inhibits	gene	0.60
DEPRESSION	associated_with	gene	0.60
DNA	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
ITGB1	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
LINGO3	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
FKBP5	interacts_with	gene	0.60
ITGB1	interacts_with	gene	0.60
LINGO3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SKA2 in their description or question text

No additional research found