Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Syntaxin 3 gene encoding a SNARE protein critical for synaptic vesicle exocytosis and membrane fusion in neurons - implicated in Alzheimer's, Parkinson's, and neurodevelopmental disorders
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| Gene Symbol | STX3 |
| Full Name | Syntaxin 3 |
| Aliases | Syntaxin 3 gene encoding a SNARE protein critical for synaptic vesicle exocytosis and membrane fusion in neurons |
| Chromosome | 11q12.1 |
| Function | Vesicle docking: STX3 localizes to the plasma membrane at the active zone and interacts with vesicle-associated VAMP2 |
| Primary Expression | astrocytes where it regulates[@tomm2019]: |
| Amino Acids | 289 aa |
| Pathways | Autophagy |
| UniProt ID | [Q99986](https://www.uniprot.org/uniprot/Q99986) |
| Ensembl ID | ENSG00000166900 |
| OMIM | 600078 |
| GeneCards | STX3 |
| Human Protein Atlas | STX3 |
| STX3 | Target membrane Q-SNARE |
| SNAP25 | Synaptosome-associated protein (two SNARE motifs) |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["STX3"]
N1["Alzheimer"]
N0 -->|"regulates"| N1
N2["Neurodegeneration"]
N0 -->|"regulates"| N2
N3["Cancer"]
N0 -->|"regulates"| N3
N4["Als"]
N0 -->|"regulates"| N4
N5["Neuroinflammation"]
N0 -->|"regulates"| N5
N6["FKBP5"]
N0 -->|"regulates"| N6
N7["SEC22B"]
N0 -->|"regulates"| N7
N8["SNAP23"]
N0 -->|"regulates"| N8
N9["Autophagy"]
N0 -->|"regulates"| N9
N10["Microglia"]
N0 -->|"regulates"| N10
N11["HSP90"]
N11 -->|"regulates"| N0
N12["ALZHEIMER"]
N12 -->|"regulates"| N0
N13["SNAP29"]
N13 -->|"regulates"| N0
N14["MICROGLIA"]
N14 -->|"regulates"| N0
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
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classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 disease
class N5 disease
class N6 gene
class N7 gene
class N8 gene
class N9 pathway
class N11 gene
class N12 gene
class N13 gene
class N14 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Autophagy | regulates | pathway | 0.60 |
| Microglia | regulates | cell_type | 0.60 |
| FKBP5 | regulates | gene | 0.60 |
| SEC22B | regulates | gene | 0.60 |
| SNAP23 | regulates | gene | 0.60 |
| VTI1B | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STX3 in their description or question text
No additional research found