gene

SEC22B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEC22B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

16Outgoing

12Incoming

0Experiments

0Debates

Summary

SEC22B (Synaptotagmin Binding Protein) - SNARE protein involved in ER-Golgi vesicle trafficking, synaptic function, and neurodegenerative disease mechanisms

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🧬 Gene Info

Gene Symbol	SEC22B
Full Name	Synaptotagmin Binding Protein
Chromosome	1q21.2
Function	is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family that plays essential roles in intracellular membrane trafficking.
Amino Acids	215 aa
Pathways	Autophagy
UniProt ID	[O75396](https://www.uniprot.org/uniprot/O75396)
Ensembl ID	ENSG00000169933
OMIM	607048
GeneCards	SEC22B
Human Protein Atlas	SEC22B
N-terminal transmembrane region	A short helical transmembrane domain that anchors the protein to vesicle membranes
SNARE motif	A conserved region of approximately 60-70 amino acids that participates in SNARE complex formation
Proline-rich domain	Located in the central region, involved in protein-protein interactions
C-terminal variable region	Contributes to specificity in SNARE pairing
Associated Diseases	neurodegeneration
Interactions	RTN3, SQSTM1, TH, WDR45, XBP1
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SEC22B Gene

gene · 1791 words

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Pathway Diagram

flowchart TD
    N0["SEC22B"]
    N1["Alzheimer"]
    N0 -->|"regulates"| N1
    N2["Neurodegeneration"]
    N0 -->|"regulates"| N2
    N3["Cancer"]
    N0 -->|"regulates"| N3
    N4["Als"]
    N0 -->|"regulates"| N4
    N5["Neuroinflammation"]
    N0 -->|"regulates"| N5
    N6["SNAP23"]
    N0 -->|"regulates"| N6
    N7["Autophagy"]
    N0 -->|"regulates"| N7
    N8["Microglia"]
    N0 -->|"regulates"| N8
    N9["HSP90"]
    N9 -->|"regulates"| N0
    N10["ALZHEIMER"]
    N10 -->|"regulates"| N0
    N11["SNAP29"]
    N11 -->|"regulates"| N0
    N12["MICROGLIA"]
    N12 -->|"regulates"| N0
    N13["LYSOSOME"]
    N13 -->|"regulates"| N0
    N14["STX4"]
    N14 -->|"regulates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 disease
    class N6 gene
    class N7 pathway
    class N9 gene
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene

Outgoing (16)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Autophagy	regulates	pathway	0.60
Microglia	regulates	cell_type	0.60
SNARE	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
SNAP23	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
TH	interacts_with	gene	0.60
WDR45	interacts_with	gene	0.60
XBP1	interacts_with	gene	0.60
STX3	regulates	gene	0.60
VTI1B	regulates	gene	0.60

Incoming (12)

Source	Relation	Type	Str
PARK7	regulates	gene	0.60
HSP90	regulates	gene	0.60
SNAP29	regulates	gene	0.60
STX4	regulates	gene	0.60
STX3	regulates	gene	0.60
FKBP5	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
SKA2	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
RTN3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SEC22B in their description or question text

No additional research found