gene

LINGO3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LINGO3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

20Outgoing

13Incoming

0Experiments

0Debates

Summary

LINGO3 gene - neurite outgrowth inhibitor

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🧬 Gene Info

Gene Symbol	LINGO3
Full Name	Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3
Aliases	LINGO3 gene
Chromosome	19q13.42
Function	LINGO3 is a member of the leucine-rich repeat and immunoglobulin-like domain (LRR+Ig) family of transmembrane proteins.
Primary Expression	the nervous system and plays a role in neurite outgrowth and axon guidance
Pathways	epigenetic regulation
UniProt ID	Q9H2Y7
NCBI Gene ID	158046
Ensembl ID	ENSG00000125845
OMIM	616233
GeneCards	LINGO3
Human Protein Atlas	LINGO3
Associated Diseases	Als, Depression
Interactions	BDNF, FKBP5, ITGB1, SKA2
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LINGO3 — AlphaFold Q9H2Y7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LINGO3 Gene

gene · 602 words

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Pathway Diagram

graph TD
    LINGO3["LINGO3"]
    Als{"Als"}
    LINGO3 -->|"associated_with"| Als
    Depression{"Depression"}
    LINGO3 -->|"associated_with"| Depression
    ALS{"ALS"}
    LINGO3 -->|"associated_with"| ALS
    NR3C1(["NR3C1"])
    LINGO3 -->|"associated_with"| NR3C1
    SLC6A4(["SLC6A4"])
    LINGO3 -->|"associated_with"| SLC6A4
    Dna_Methylation["Dna Methylation"]
    LINGO3 -->|"associated_with"| Dna_Methylation
    DEPRESSION(["DEPRESSION"])
    DEPRESSION -->|"associated_with"| LINGO3
    SKA2(["SKA2"])
    SKA2 -->|"associated_with"| LINGO3
    FKBP5(["FKBP5"])
    FKBP5 -->|"associated_with"| LINGO3
    DNA(["DNA"])
    DNA -->|"associated_with"| LINGO3
    style LINGO3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (20)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
ALS	associated_with	disease	0.65
SKA2	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
SKA2	interacts_with	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
FKBP5	associated_with	gene	0.60
Dna Methylation	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
DNA	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
ITGB1	associated_with	gene	0.60
Bdnf	associated_with	protein	0.60
App	associated_with	protein	0.60
FKBP5	interacts_with	concept	0.50
NR3C1	co_expressed_with	gene	0.50
SLC6A4	co_expressed_with	protein	0.50

Incoming (13)

Source	Relation	Type	Str
DEPRESSION	associated_with	gene	0.60
SKA2	associated_with	gene	0.60
DNA	associated_with	gene	0.60
ITGB1	associated_with	gene	0.60
FKBP5	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
ITGB1	interacts_with	gene	0.60
FKBP5	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
DEPRESSION	interacts_with	disease	0.50
BDNF	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LINGO3 in their description or question text

No additional research found