gene

SNAP23

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNAP23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

31Outgoing

23Incoming

0Experiments

0Debates

Summary

SNAP23 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Alzheimer, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SNAP23
Chromosome	15q21.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	all neurons
Molecular Weight	23 kDa
Exons	6 coding exons
Pathways	Autophagy
Ensembl ID	ENSG00000100939
GeneCards	SNAP23
Human Protein Atlas	SNAP23
Location	Chromosome 15q21.3
Gene Length	~6 kb
Alternative Splicing	Two transcript variants
Neurotransmitter release	Vesicle fusion at synapse
Exocytosis	Hormone and enzyme secretion
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOPTOSIS, APP
KG Connections	54 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SNAP23 Gene

gene · 629 words

→

SNAP23 Protein

protein · 702 words

→

Pathway Diagram

graph TD
    SNAP23["SNAP23"]
    Alzheimer{"Alzheimer"}
    SNAP23 -->|"activates"| Alzheimer
    Ms{"Ms"}
    SNAP23 -->|"activates"| Ms
    Autophagy(["Autophagy"])
    SNAP23 -->|"activates"| Autophagy
    APP["APP"]
    SNAP23 -->|"activates"| APP
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    SNAP23 -->|"activates"| NEURODEGENERATIVE_DISEASES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    SNAP23 -->|"activates"| ALZHEIMER_S_DISEASE
    APP_PS1["APP/PS1"]
    SNAP23 -->|"activates"| APP_PS1
    TAU["TAU"]
    SNAP23 -->|"activates"| TAU
    AUTOPHAGY["AUTOPHAGY"]
    SNAP23 -->|"activates"| AUTOPHAGY
    NEUROTOXICITY["NEUROTOXICITY"]
    SNAP23 -->|"activates"| NEUROTOXICITY
    neurodegeneration["neurodegeneration"]
    SNAP23 -->|"implicated in"| neurodegeneration
    APP -->|"activates"| SNAP23
    APP_PS1 -->|"activates"| SNAP23
    style SNAP23 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
SNARE	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
ZBP1	activates	gene	0.60
BAX	activates	gene	0.60
HERC5	activates	gene	0.60
STX4	activates	gene	0.60
STX4	inhibits	gene	0.60
Autophagy	activates	pathway	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP/PS1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
AMYLOID	activates	gene	0.60
Autophagy	regulates	pathway	0.60
Microglia	regulates	cell_type	0.60
RFK	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
CHAC1	activates	gene	0.60
Caspase	activates	protein	0.60

Incoming (23)

Source	Relation	Type	Str
AND	activates	gene	0.60
APP	activates	gene	0.60
HSP90	regulates	gene	0.60
SNAP29	regulates	gene	0.60
STX4	regulates	gene	0.60
STX3	regulates	gene	0.60
FKBP5	regulates	gene	0.60
SEC22B	regulates	gene	0.60
ISG15	activates	gene	0.60
RAB8A	inhibits	gene	0.60
RAB8A	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
SKA2	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CMPK2	activates	gene	0.60
TAU	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
LYSOSOME	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SNAP23 in their description or question text

No additional research found