gene

STX4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STX4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

25Outgoing

19Incoming

0Experiments

0Debates

Summary

STX4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms, Parkinson. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STX4
Full Name	Syntaxin-4
Chromosome	16p12.1
Function	STX4 encodes syntaxin-4, a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) family.
Subcellular Localization	intracellular compartments, STX4 is uniquely positioned at the plasma membrane, where it mediates exocytosis and maintai
Pathways	Autophagy
UniProt ID	Q12846
NCBI Gene ID	6814
Ensembl ID	ENSG00000128415
GeneCards	STX4
Human Protein Atlas	STX4
Associated Diseases	Als, Ms, Parkinson
Interactions	RAB8A, SNAP23, SNARE
KG Connections	44 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STX4 — AlphaFold Q12846 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

STX4 — Syntaxin-4

gene · 606 words

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STX4A — Syntaxin 4A

gene · 1928 words

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Pathway Diagram

graph TD
    STX4["STX4"]
    Parkinson{"Parkinson"}
    STX4 -->|"associated with"| Parkinson
    Als{"Als"}
    STX4 -->|"associated with"| Als
    Ms{"Ms"}
    STX4 -->|"associated with"| Ms
    LDLR["LDLR"]
    STX4 -->|"associated with"| LDLR
    HSPB1["HSPB1"]
    STX4 -->|"associated with"| HSPB1
    APOA2["APOA2"]
    STX4 -->|"associated with"| APOA2
    LGALS3["LGALS3"]
    STX4 -->|"associated with"| LGALS3
    CSNK2A1["CSNK2A1"]
    STX4 -->|"associated with"| CSNK2A1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    STX4 -->|"associated with"| NEURODEGENERATIVE_DISORDERS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    STX4 -->|"associated with"| PARKINSON_S_DISEASE
    PARKINSON["PARKINSON"]
    STX4 -->|"associated with"| PARKINSON
    AND["AND"]
    STX4 -->|"associated with"| AND
    PARKINSON_S_DISEASE -->|"associated with"| STX4
    style STX4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
autophagy pathway	participates_in	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Microglia	regulates	cell_type	0.60
SKA2	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
CSNK2A1	associated_with	gene	0.60
STX3	regulates	gene	0.60
FKBP5	regulates	gene	0.60
SEC22B	regulates	gene	0.60
HSPB1	associated_with	gene	0.60
SNAP23	regulates	gene	0.60
LDLR	associated_with	gene	0.60
APOA2	associated_with	gene	0.60

Incoming (19)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
RAB8A	inhibits	gene	0.60
SNAP23	inhibits	gene	0.60
RAB8A	activates	gene	0.60
HSP90	regulates	gene	0.60
SNAP29	regulates	gene	0.60
SNAP23	activates	gene	0.60
HSPB1	associated_with	gene	0.60
SNARE	activates	gene	0.60
APOA2	associated_with	gene	0.60
CSNK2A1	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
SNARE	regulates	gene	0.55
STX17	regulates	gene	0.55
STX1A	regulates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STX4 in their description or question text

No additional research found