gene

PLA2G4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLA2G4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

PLA2G4A is a gene implicated in neurodegeneration research. Key relationships include: co discussed, inhibits, associated with. Associated with ALS, Als, Ms. Connected to 45 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLA2G4A
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor of cytosolic phospholipase A2 enzymatic activity
Mechanism of Action	Small molecule inhibitor of cytosolic phospholipase A2 enzymatic activity
Druggability	Low (0.40)
Clinical Stage	Phase II
Pathways	Cellular senescence / SASP signaling, Prostaglandin Biosynthesis
UniProt ID	P47712
GeneCards	PLA2G4A
Human Protein Atlas	PLA2G4A
Associated Diseases	Als, erotomanic delusion, Ms, neurodegeneration, poverty of thought
Known Drugs/Compounds	PYR-1
Interactions	ACTB, AND, ATG12, ATG5, ATG7, AUTOPHAGY
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	131 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PLA2G4A — AlphaFold P47712 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    PLA2G4A["PLA2G4A"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PLA2G4A["PLA2G4A"] -->|"interacts"| PLA2G6["PLA2G6"]
    PLA2G6_1["PLA2G6"] -->|"interacts"| PLA2G4A["PLA2G4A"]
    MMP9["MMP9"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    SLC7A11["SLC7A11"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    AQP4["AQP4"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    style PLA2G4A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
Schizophrenia	risk_factor_for	disease	0.95
cytosolic phospholipase A2	associated_with	protein	0.95
Cytosolic PLA2	regulates	protein	0.92
Copy Number Deletion	associated_with	mechanism	0.90
Cpla2	regulates	protein	0.90
Cytosolic Phospholipase A2	regulates	protein	0.90
Cytosolic Phospholipase A2	biomarker_for	biomarker	0.85
Poverty Of Thought	correlates_with	phenotype	0.85
Erotomanic Delusion	correlates_with	phenotype	0.85
schizophrenia	affects	disease	0.80
erotomanic delusion	associated_with	phenotype	0.75
poverty of thought	associated_with	phenotype	0.75
Neurodegeneration	inhibits	disease	0.65
Ms	causes	disease	0.65
ALS	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
Ms	activates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Interferon	inhibits	protein	0.60
Rb	inhibits	protein	0.60
TAU	expressed_in	entity	0.60
schizophrenia	associated_with	disease	0.60
PLA2G6	upregulates	entity	0.60
PLA2G6	regulates	entity	0.60
PLA2G6	expressed_in	entity	0.60
SCHIZOPHRENIA	upregulates	entity	0.60
SCHIZOPHRENIA	expressed_in	entity	0.60
AUTOPHAGY	inhibits	gene	0.60
PLA2G4F	interacts_with	gene	0.60
Alzheimer's disease	activates	disease	0.60
traumatic brain injury	activates	disease	0.60
RNA	activates	gene	0.60
schizophrenia	interacts_with	disease	0.60
neurodegeneration	activates	disease	0.60
RBFOX3	activates	gene	0.60
GENES	expressed_in	gene	0.60
autophagy pathway	participates_in	pathway	0.60
neurodegeneration	associated_with	disease	0.60
Autophagy	inhibits	pathway	0.60
T Cell	activates	cell_type	0.60
PLA2G6	associated_with	gene	0.60
SCHIZOPHRENIA	associated_with	disease	0.60
PLA2G6	inhibits	gene	0.60
TAU	inhibits	gene	0.60
schizophrenia	biomarker_for	disease	0.60
schizophrenia	expressed_in	disease	0.60
PLA2G3	activates	gene	0.60
PLA2G6	treats	gene	0.60
PLA2G12F	activates	gene	0.60

Incoming (54)

Source	Relation	Type	Str
Copy number deletion	downregulates	process	0.90
PYR-1	inhibits	drug	0.90
h-bb518928	targets	hypothesis	0.90
IFNT	downregulates	protein	0.85
PDBu	upregulates	drug	0.85
PLA2G6	inhibits	gene	0.60
ACTB	activates	gene	0.60
ATG12	activates	gene	0.60
ATG5	activates	gene	0.60
PLA2G12F	interacts_with	gene	0.60
BECN1	activates	gene	0.60
CTSD	activates	gene	0.60
CTSL	activates	gene	0.60
LAMP1	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3	activates	gene	0.60
NAGLU	activates	gene	0.60
ATG7	activates	gene	0.60
PLA2G3	interacts_with	gene	0.60
AND	inhibits	gene	0.60
PLA2G6	activates	gene	0.60
PLA2G12F	activates	gene	0.60
PLA2G3	activates	gene	0.60
PLA2G4F	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
TAU	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
MBP	expressed_in	gene	0.55
ERK1	activates	gene	0.55
SCHIZOPHRENIA	associated_with	disease	0.50
SCHIZOPHRENIA	activates	disease	0.50
SCHIZOPHRENIA	inhibits	disease	0.50
PLA2G6	regulates	gene	0.50
PLA2G6	expressed_in	gene	0.50
PLA2G6	associated_with	gene	0.50
PLA2G6	interacts_with	gene	0.48
P38	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
NAMPT	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
PLA2G6	co_discussed	gene	0.40
MMP2	co_discussed	gene	0.40
C3	co_discussed	gene	0.40
CGAS	co_discussed	gene	0.40
IL1B	co_discussed	gene	0.40
DNASE2	co_discussed	gene	0.40
STING1	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.782

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning PLA2G4A in their description or question text

No additional research found