gene

DNASE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNASE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

1Analyses

43Outgoing

25Incoming

0Experiments

1Debates

Summary

DNASE2 is a gene implicated in neurodegeneration research. Key relationships include: co discussed, interacts with, therapeutic target. Associated with neurodegeneration. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNASE2
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor or activator of nuclease activity
Mechanism of Action	Small molecule inhibitor or activator of nuclease activity
Druggability	Low (0.30)
Clinical Stage	Phase I
Pathways	Mitochondrial dynamics / bioenergetics
UniProt ID	O00115
GeneCards	DNASE2
Human Protein Atlas	DNASE2
Associated Diseases	als, Developmental delay, Glomerulonephritis, Lupus, Microcephaly, ms
Known Drugs/Compounds	No specific inhibitors
Interactions	CGAS, IRF3, STING1
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	68 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNASE2 — AlphaFold O00115 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    DNASE2["DNASE2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    DNASE2["DNASE2"] -->|"interacts"| CGAS["CGAS"]
    DNASE2["DNASE2"] -->|"interacts"| STING1["STING1"]
    DNASE2["DNASE2"] -->|"co discussed"| STING1_1["STING1"]
    DNASE2["DNASE2"] -->|"co discussed"| C3["C3"]
    DNASE2["DNASE2"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    CGAS_2["CGAS"] -->|"interacts"| DNASE2["DNASE2"]
    STING1_3["STING1"] -->|"interacts"| DNASE2["DNASE2"]
    MMP9["MMP9"] -->|"co discussed"| DNASE2["DNASE2"]
    SLC7A11["SLC7A11"] -->|"co discussed"| DNASE2["DNASE2"]
    style DNASE2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (43)

Target	Relation	Type	Str
Aging	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Dna Repair	expressed_in	pathway	0.60
T Cell	expressed_in	cell_type	0.60
Complement	expressed_in	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
Fus	expressed_in	protein	0.60
GCDH	associated_with	gene	0.60
Ras	contributes_to	protein	0.60
neurodegeneration	associated_with	disease	0.60
DNA	degrades	gene	0.60
App	expressed_in	protein	0.60
Microcephaly	associated_with	disease	0.60
Polyarthritis	associated_with	disease	0.60
Glomerulonephritis	associated_with	disease	0.60
Developmental delay	associated_with	disease	0.60
Lupus	causes	disease	0.60
White Matter	expressed_in	brain_region	0.55
STING1	activates	gene	0.55
neuroinflammation	activates	process	0.55
IRF3	activates	gene	0.55
Temporal Lobe	expressed_in	brain_region	0.55
Mitochondrial dynamics / bioenergetics	participates_in	pathway	0.54
STING1	interacts_with	gene	0.53
CGAS	interacts_with	gene	0.53
DNA DAMAGE	associated_with	concept	0.50
Lupus	associated_with	disease	0.50
CD38	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
SLC7A11	co_discussed	gene	0.40
MMP2	co_discussed	gene	0.40
MMP9	co_discussed	gene	0.40
IL1B	co_discussed	gene	0.40
CGAS	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
PLA2G4A	co_discussed	gene	0.40
STING1	co_discussed	gene	0.40
NAMPT	co_discussed	gene	0.40
C3	co_discussed	gene	0.40
als	implicated_in	disease	0.35
ms	implicated_in	disease	0.35

Incoming (25)

Source	Relation	Type	Str
h-1a34778f	targets	hypothesis	0.90
RAD54	expressed_in	gene	0.60
DSDNA	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
DNA	degrades	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CGAS	activates	gene	0.55
STING1	interacts_with	gene	0.53
CGAS	interacts_with	gene	0.53
CGAS	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
CD38	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
MMP9	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
PLA2G6	co_discussed	gene	0.40
IL1B	co_discussed	gene	0.40
MMP2	co_discussed	gene	0.40
NAMPT	co_discussed	gene	0.40
SLC7A11	co_discussed	gene	0.40
PLA2G4A	co_discussed	gene	0.40
STING1	co_discussed	gene	0.40
C3	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning DNASE2 in their description or question text

No additional research found