concept

UBIQUITIN-PROTEASOME SYSTEM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBIQUITIN-PROTEASOME SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

0Experiments

0Debates

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💡 Concept Info

Name	UBIQUITIN-PROTEASOME SYSTEM
Key Genes/Proteins	AKT, ALPHA-SYNUCLEIN, AMPK, ATG5, BECN1, C9orf72
Related Diseases	ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, DEMENTIA, DOPAMINE

Pathway Diagram

graph TD
    UBIQUITIN_PROTEASOME_SYSTEM["UBIQUITIN-PROTEASOME SYSTEM"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involved_in"| Muscle_Protein_Degradation["Muscle Protein Degradation"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involved_in"| Proteostasis["Proteostasis"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involved_in"| Cancer_Hallmarks["Cancer Hallmarks"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"interacts"| Autophagy["Autophagy"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"mediates"| Muscle_Cell_Atrophy["Muscle Cell Atrophy"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involves"| UBIQUITIN["UBIQUITIN"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"regulates"| protein_expression["protein expression"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"modulates"| protein_function["protein function"]
    P62["P62"] -->|"involved_in"| UBIQUITIN_PROTEASOME_SYSTEM
    UBIQUITIN -->|"component_of"| UBIQUITIN_PROTEASOME_SYSTEM
    E3_Ubiquitin_Ligases["E3 Ubiquitin Ligases"] -->|"regulates"| UBIQUITIN_PROTEASOME_SYSTEM
    Obestatin["Obestatin"] -->|"regulates"| UBIQUITIN_PROTEASOME_SYSTEM
    Proteolysis_Targeting_Chimeras["Proteolysis-Targeting Chimeras"] -->|"targets"| UBIQUITIN_PROTEASOME_SYSTEM
    OBESTATIN["OBESTATIN"] -->|"regulates"| UBIQUITIN_PROTEASOME_SYSTEM
    Autophagy_Deficiency["Autophagy Deficiency"] -->|"inhibits"| UBIQUITIN_PROTEASOME_SYSTEM

Outgoing (86)

Target	Relation	Type	Str
Protein Turnover	regulates	process	0.95
Muscle Protein Degradation	involved_in	process	0.95
Proteostasis	associated_with	process	0.95
Signaling	regulates	process	0.95
Cancer Hallmarks	involved_in	process	0.95
Disease-Associated Proteins	degrades	protein	0.90
Cancer-Associated Pathways	regulates	pathway	0.90
Metabolic Reprogramming	involved_in	process	0.90
Autophagy	interacts_with	process	0.90
Muscle Cell Atrophy	mediates	phenotype	0.90
Protein Aggregates	degrades	mechanism	0.90
cellular homeostasis	associated_with	process	0.90
Muscle Cell Atrophy	involved_in	phenotype	0.90
proteostasis	regulates	process	0.90
UBIQUITIN	involves	protein	0.90
protein expression	regulates	process	0.90
protein function	modulates	process	0.90
Neurodegeneration	associated_with	disease	0.85
Protein Clearance	involved_in	process	0.85
Cancer	associated_with	disease	0.85
cancer-associated pathways	regulates	pathway	0.85
metabolic reprogramming	modulates	process	0.85
neurodegeneration	associated_with	disease	0.85
SNCA	involved_in	protein	0.85
TDP-43	degrades	protein	0.85
Metabolic Reprogramming	regulates	process	0.85
Immune Dysfunction	associated_with	disease	0.85
Tumor Immune Response	modulates	process	0.85
Tumor Immune Response	involved_in	process	0.85
Phenotypic Plasticity	involved_in	phenotype	0.85
breast cancer progression	regulates	process	0.82
Glucocorticoid-Induced Muscle Atrophy	involved_in	disease	0.80
tumor immune responses	regulates	process	0.80
Protein Degradation	mediates	process	0.75
EV-A71 Infection	involved_in	process	0.75
TP53	regulates	gene	0.75
alpha-synuclein	regulates	protein	0.70
Parkinson's disease	associated_with	disease	0.70
protein degradation	regulates	process	0.70
AUTOPHAGY	regulates	phenotype	0.65
Alzheimer disease	involved_in	disease	0.60
DOPAMINE	participates_in	phenotype	0.55
ROS	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
DEMENTIA	associated_with	disease	0.45
TAU	associated_with	protein	0.45
SENESCENCE	associated_with	phenotype	0.45
RAPAMYCIN	associated_with	drug	0.45
SQSTM1	associated_with	gene	0.45

Incoming (34)

Source	Relation	Type	Str
P62	involved_in	protein	0.95
E3 Ubiquitin Ligases	regulates	enzyme	0.95
HK2	associated_with	gene	0.95
UBIQUITIN	involved_in	protein	0.95
UBIQUITIN	component_of	protein	0.95
Obestatin	regulates	compound	0.92
SPASTIN	involved_in	protein	0.90
P62	links	protein	0.90
Parkin	involved_in	enzyme	0.90
Proteolysis-Targeting Chimeras	targets	drug	0.90
Antibody-Based Degraders	targets	drug	0.85
Molecular Glues	targets	drug	0.85
Cancer-Associated Pathways	associated_with	pathway	0.85
OBST	regulates	protein	0.85
OBESTATIN	regulates	protein	0.85
OBESTATIN	modulates	protein	0.85
SPAST	involved_in	protein	0.85
GBA1	involved_in	gene	0.85
Autophagy Deficiency	inhibits	phenotype	0.80
VPS35	regulates	protein	0.80
OBESTATIN	controls	protein	0.80
LRRK2	involved_in	protein	0.80
Oxidative Stress	inhibits	process	0.75
GBA1	regulates	gene	0.70
USP14	regulates	protein	0.70
ROS	activates	phenotype	0.65
OXIDATIVE STRESS	protects_against	phenotype	0.65
VCP	activates	gene	0.65
VCP	degrades	gene	0.65
NRF2	targets	gene	0.65
UBIQUITIN	targets	protein	0.65
PARK7	involved_in	gene	0.60
VCP	participates_in	gene	0.55
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBIQUITIN-PROTEASOME SYSTEM in their description or question text

No additional research found