mechanism

sumoylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about sumoylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections
2Hypotheses
1Analyses
4Outgoing
5Incoming
0Experiments
2Debates

Summary

Protein Sumoylation In Neurodegeneration is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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Mechanism Info
Namesumoylation

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

sumoylation

mechanism · 2034 words

Pathway Diagram

flowchart TD
    SUMOylation["SUMOylation"] -->|"modulates"| Proteostatic_Integrity["Proteostatic Integrity"]
    SUMOylation["SUMOylation"] -->|"modulates"| Proteostasis["Proteostasis"]
    Sumoylation["Sumoylation"] -->|"regulates"| Circadian_Clock_Gene_Regulatio["Circadian Clock Gene Regulation"]
    ANXA1["ANXA1"] -->|"involved in"| Sumoylation["Sumoylation"]
    __SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"involved in"| Sumoylation["Sumoylation"]
    Tardbp["Tardbp"] -->|"associated with"| SUMOylation["SUMOylation"]
    ANXA1["ANXA1"] -->|"undergoes"| SUMOYLATION["SUMOYLATION"]
    style SUMOylation fill:#5d4400,stroke:#333,color:#e0e0e0
    style Proteostatic_Integrity fill:#5d4400,stroke:#333,color:#e0e0e0
    style Proteostasis fill:#5d4400,stroke:#333,color:#e0e0e0
    style Sumoylation fill:#5d4400,stroke:#333,color:#e0e0e0
    style Circadian_Clock_Gene_Regulatio fill:#5d4400,stroke:#333,color:#e0e0e0
    style ANXA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style __SYNUCLEIN fill:#006494,stroke:#333,color:#e0e0e0
    style Tardbp fill:#006494,stroke:#333,color:#e0e0e0
    style SUMOYLATION fill:#5d4400,stroke:#333,color:#e0e0e0

Outgoing (4)

TargetRelationTypeStr
Proteostatic Integritymodulatesprocess0.72
Proteostasismodulatesprocess0.70
tau loading into exosomesmodulatesmechanism0.70
Circadian Clock Gene Regulationregulatesprocess0.70

Incoming (5)

SourceRelationTypeStr
ANXA1involved_inprotein0.90
ANXA1involved_inprotein0.85
Α-SYNUCLEINinvolved_inprotein0.85
Tardbpassociated_withprotein0.85
ANXA1undergoesgene0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs 0.652 neurodegeneration What are the specific PTM changes in syn
Targeting AQP4 Sumoylation to Enhance Glymphatic Clearance a 0.490 neurodegeneration What are the specific molecular mechanis

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene Co-expression Network Analysis of AD Progression Modules

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (2)

Multi-agent debates referencing this entity

What co-expression modules are shared and unique across brain regions in AD, and

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Is TYROBP a genuine therapeutic target in AD, or is it a downstream marker of mi

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning sumoylation in their description or question text

No additional research found