Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about sumoylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Protein Sumoylation In Neurodegeneration is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
No AI portrait yet
| Name | sumoylation |
Knowledge base pages for this entity
flowchart TD
SUMOylation["SUMOylation"] -->|"modulates"| Proteostatic_Integrity["Proteostatic Integrity"]
SUMOylation["SUMOylation"] -->|"modulates"| Proteostasis["Proteostasis"]
Sumoylation["Sumoylation"] -->|"regulates"| Circadian_Clock_Gene_Regulatio["Circadian Clock Gene Regulation"]
ANXA1["ANXA1"] -->|"involved in"| Sumoylation["Sumoylation"]
__SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"involved in"| Sumoylation["Sumoylation"]
Tardbp["Tardbp"] -->|"associated with"| SUMOylation["SUMOylation"]
ANXA1["ANXA1"] -->|"undergoes"| SUMOYLATION["SUMOYLATION"]
style SUMOylation fill:#5d4400,stroke:#333,color:#e0e0e0
style Proteostatic_Integrity fill:#5d4400,stroke:#333,color:#e0e0e0
style Proteostasis fill:#5d4400,stroke:#333,color:#e0e0e0
style Sumoylation fill:#5d4400,stroke:#333,color:#e0e0e0
style Circadian_Clock_Gene_Regulatio fill:#5d4400,stroke:#333,color:#e0e0e0
style ANXA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style __SYNUCLEIN fill:#006494,stroke:#333,color:#e0e0e0
style Tardbp fill:#006494,stroke:#333,color:#e0e0e0
style SUMOYLATION fill:#5d4400,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Proteostatic Integrity | modulates | process | 0.72 |
| Proteostasis | modulates | process | 0.70 |
| tau loading into exosomes | modulates | mechanism | 0.70 |
| Circadian Clock Gene Regulation | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ANXA1 | involved_in | protein | 0.90 |
| ANXA1 | involved_in | protein | 0.85 |
| Α-SYNUCLEIN | involved_in | protein | 0.85 |
| Tardbp | associated_with | protein | 0.85 |
| ANXA1 | undergoes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SUMO1-Mediated Synaptotagmin-1 SUMOylation at Lys124 Impairs | 0.652 | neurodegeneration | What are the specific PTM changes in syn |
| Targeting AQP4 Sumoylation to Enhance Glymphatic Clearance a | 0.490 | neurodegeneration | What are the specific molecular mechanis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning sumoylation in their description or question text
No additional research found