concept

MTOR PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MTOR PATHWAY
Key Genes/Proteins	ACSL4, AKT, AMPK, AMYLOID, APOE, APP
Related Diseases	AGING, ALZHEIMER'S DISEASE, AUTOPHAGY, BREAST CANCER

Pathway Diagram

graph TD
    MTOR_PATHWAY["MTOR PATHWAY"]
    MTOR_PATHWAY -->|"inhibits"| autophagy["autophagy"]
    MTOR_PATHWAY -->|"mediates"| Offspring_Stem_Cell_Programmin["Offspring Stem Cell Programming"]
    MTOR_PATHWAY -->|"activates"| Vascular_Niche_Formation["Vascular Niche Formation"]
    MTOR_PATHWAY -->|"regulates"| Autophagy["Autophagy"]
    MTOR_PATHWAY -->|"causes"| epilepsy["epilepsy"]
    MTOR_PATHWAY -->|"contributes to"| neuronal_excitability["neuronal excitability"]
    MTOR_PATHWAY -->|"involved_in"| Salidroside_Induced_Cell_Death["Salidroside-Induced Cell Death"]
    AKT["AKT"] -->|"upstream_of"| MTOR_PATHWAY
    Lyso_ChR2["Lyso-ChR2"] -->|"activates"| MTOR_PATHWAY
    PI3K_AKT_pathway["PI3K-AKT pathway"] -->|"interacts"| MTOR_PATHWAY
    Hearing_Loss["Hearing Loss"] -->|"activates"| MTOR_PATHWAY
    Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"activates"| MTOR_PATHWAY
    Ferroptosis["Ferroptosis"] -->|"involved_in"| MTOR_PATHWAY
    MTOR["MTOR"] -->|"activates"| MTOR_PATHWAY
    CANCER["CANCER"] -->|"activates"| MTOR_PATHWAY

Outgoing (78)

Target	Relation	Type	Str
Offspring Stem Cell Programming	mediates	process	0.90
autophagy	inhibits	pathway	0.90
Cancer	associated_with	disease	0.85
Type 2 Diabetes	associated_with	disease	0.85
Autophagy	regulates	process	0.85
Vascular Niche Formation	activates	process	0.85
Salidroside-Induced Cell Death	involved_in	mechanism	0.80
Autophagy	modulates	process	0.80
Amyloid-Beta	regulates	protein	0.80
Autophagy	regulates	pathway	0.80
epilepsy	causes	disease	0.80
neuronal excitability	contributes_to	phenotype	0.80
Perivascular Neuroprotection	associated_with	process	0.75
ageing	regulates	process	0.70
CELL DEATH	activates	phenotype	0.65
PIK3CA	regulates	gene	0.65
AUTOPHAGY	treats	phenotype	0.65
AGING	regulates	phenotype	0.65
AGING	treats	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
BREAST CANCER	inhibits	disease	0.65
AGING	targets	phenotype	0.65
REMYELINATION	implicated_in	phenotype	0.55
HK2	associated_with	gene	0.50
TNF	associated_with	gene	0.50
APOE	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
MITOPHAGY	associated_with	phenotype	0.50
APP	associated_with	gene	0.50
TAU	associated_with	protein	0.50
LDLR	associated_with	gene	0.50
AMYLOID	associated_with	protein	0.50
PARKIN	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
CELL DEATH	associated_with	phenotype	0.45
SLC7A11	associated_with	gene	0.45
GPX4	associated_with	gene	0.45
PIK3CA	associated_with	gene	0.45
STEM CELLS	associated_with	cell_type	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CYTOKINES	associated_with	phenotype	0.45
FIBROSIS	associated_with	disease	0.45
SNAP25	associated_with	gene	0.45
FIBROBLASTS	associated_with	cell_type	0.45
TSC1	associated_with	gene	0.45
TSC2	associated_with	gene	0.45
RHEB	associated_with	gene	0.45
PSORIASIS	associated_with	disease	0.45
IDH1	associated_with	gene	0.45

Incoming (134)

Source	Relation	Type	Str
AKT	upstream_of	protein	0.90
Lyso-ChR2	activates	protein	0.88
Hearing Loss	activates	phenotype	0.85
PI3K-AKT pathway	interacts_with	pathway	0.85
Short-Chain Fatty Acids	activates	compound	0.80
Ferroptosis	involved_in	process	0.75
RAPAMYCIN	treats	drug	0.65
CANCER	targets	disease	0.65
SNCA	neuroprotective	gene	0.55
NLRP3	activates	gene	0.55
PYCARD	activates	gene	0.55
TNFA	activates	gene	0.55
TGM2	involved_in	gene	0.55
FKBP5	inhibits	gene	0.55
TFRC	involved_in	gene	0.55
BCL2L1	activates	gene	0.55
DNMT1	activates	gene	0.55
SETX	activates	gene	0.55
APOE	involved_in	gene	0.55
ULK1	involved_in	gene	0.55
ULK1	inhibits	gene	0.55
MMP9	inhibits	gene	0.55
STING1	interacts_with	gene	0.55
STING1	involved_in	gene	0.55
STING1	regulates	gene	0.55
C1Q	activates	gene	0.55
FOXO1	activates	gene	0.55
GLP1R	activates	gene	0.55
PLIN2	activates	gene	0.55
SIRT3	activates	gene	0.55
SREBF2	activates	gene	0.55
CHR2	activates	gene	0.55
BDNF	interacts_with	gene	0.55
SNAP25	inhibits	gene	0.55
ACSL4	modifies	gene	0.55
GPX4	modifies	gene	0.55
SLC7A11	modifies	gene	0.55
BDNF	activates	gene	0.55
TFAM	inhibits	gene	0.55
HSP90AA1	involved_in	gene	0.55
FOXP3	involved_in	gene	0.55
BDNF	modifies	gene	0.55
PRMT1	inhibits	gene	0.55
LAMP1	inhibits	gene	0.55
MCOLN1	inhibits	gene	0.55
NLRP3	neuroprotective	gene	0.55
SIRT3	neuroprotective	gene	0.55
ULK1	expression	gene	0.55
NLRP3	involved_in	gene	0.55
SIRT3	involved_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTOR PATHWAY in their description or question text

No additional research found