concept

LONG-TERM POTENTIATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LONG-TERM POTENTIATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

347Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

LONG-TERM POTENTIATION is a concept in neurodegeneration research. Key relationships include: co discussed, promotes, inhibits. Connected to 13 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LONG-TERM POTENTIATION
Key Genes/Proteins	APOE, APP, BACE1, BDNF
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Long-Term Potentiation (LTP)

mechanism · 2356 words

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Pathway Diagram

graph TD
    LONG_TERM_POTENTIATION["LONG-TERM POTENTIATION"]
    LONG_TERM_POTENTIATION -->|"interacts"| Complement["Complement"]
    LONG_TERM_POTENTIATION -->|"interacts"| Autophagy["Autophagy"]
    LONG_TERM_POTENTIATION -->|"interacts"| Nf__b["Nf-Kappab"]
    LONG_TERM_POTENTIATION -->|"interacts"| Apoptosis["Apoptosis"]
    LONG_TERM_POTENTIATION -->|"interacts"| Synaptic_Plasticity["Synaptic Plasticity"]
    LONG_TERM_POTENTIATION -->|"interacts"| Calcium_Signaling["Calcium Signaling"]
    REK7_EphA5["REK7/EphA5"] -->|"regulates"| LONG_TERM_POTENTIATION
    PPP3R1["PPP3R1"] -->|"participates in"| LONG_TERM_POTENTIATION
    JUN["JUN"] -->|"regulates"| LONG_TERM_POTENTIATION
    ANXA1["ANXA1"] -->|"target for"| LONG_TERM_POTENTIATION
    NBR1["NBR1"] -->|"target for"| LONG_TERM_POTENTIATION
    TNF["TNF"] -->|"target for"| LONG_TERM_POTENTIATION
    NRG1["NRG1"] -->|"expressed in"| LONG_TERM_POTENTIATION
    ERBB4["ERBB4"] -->|"expressed in"| LONG_TERM_POTENTIATION
    BDNF["BDNF"] -->|"activates"| LONG_TERM_POTENTIATION
    TRKB["TRKB"] -->|"activates"| LONG_TERM_POTENTIATION

Outgoing (56)

Target	Relation	Type	Str
Learning And Memory	associated_with	phenotype	0.85
Learning and Memory	mediates	phenotype	0.85
Hippocampus	expressed_in	cell_type	0.80
APOE	treats	gene	0.60
ALS	treats	disease	0.60
SYNAPTIC PLASTICITY	treats	phenotype	0.60
ALS	stabilizes	disease	0.60
NEUROINFLAMMATION	interacts_with	phenotype	0.60
TAU	stabilizes	protein	0.60
Calcium Signaling	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
STING	co_discussed	entity	0.50
ALZHEIMER'S	regulates	concept	0.50
CA3	associated_with	brain_region	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
PSEN2	co_discussed	entity	0.50
Proteins	activates	protein	0.50
SOMATOSENSORY CORTEX	associated_with	brain_region	0.50
NMDA	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
LRRK2	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
PYRAMIDAL	co_discussed	entity	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
Protein Aggregation	activates	process	0.50
INSULIN	activates	concept	0.50
DENTATE GYRUS	associated_with	brain_region	0.50
LIPID RAFT	associated_with	organelle	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
PSD95	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
STRIATUM	interacts_with	concept	0.50
CEREBRAL CORTEX	interacts_with	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
MITOCHONDRIA	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
TFEB	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
MAPT	co_discussed	entity	0.50
P62	co_discussed	entity	0.50
SQSTM1	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
STRIATUM	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50

Incoming (291)

Source	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.95
Aη-α	inhibits	compound	0.90
lactate shuttling	mediates	process	0.90
11793011	have deficits in	paper	0.90
Beta-Amyloid Oligomers	inhibits	compound	0.88
Nrg1-Erbb4 Signaling	mediates	pathway	0.85
NRG1	regulates	gene	0.85
Parvalbumin-Containing Interneurons	involved_in	cell_type	0.85
β-amyloid Oligomers	suppresses	compound	0.85
Reduced Lactate Shuttling	associated_with	mechanism	0.85
BDNF	promotes	protein	0.82
Ketogenic Diet	associated_with	drug	0.80
REK7/EphA5	regulates	gene	0.80
COMPLEMENT	regulates	gene	0.70
ALZHEIMER'S DISEASE	inhibits	gene	0.70
PPP3R1	participates_in	gene	0.70
Alzheimer	inhibits	disease	0.70
AMYLOID	inhibits	gene	0.70
ALZHEIMER	inhibits	gene	0.70
Als	regulates	disease	0.65
PSD95	inhibits	gene	0.65
TAU	treats	protein	0.65
APP	treats	gene	0.65
APP	protects_against	gene	0.65
MICROGLIA	treats	cell_type	0.65
BACE1	inhibits	gene	0.65
NBR1	protects_against	gene	0.60
TNF	protects_against	gene	0.60
ANXA1	protects_against	gene	0.60
TRKA	associated_with	gene	0.60
TRKB	associated_with	gene	0.60
NGF	associated_with	gene	0.60
MAO	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
TRKC	associated_with	gene	0.60
GABARAP	inhibits	gene	0.60
LC3B	associated_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
APP	regulates	gene	0.60
TRKC	regulates	gene	0.60
NRG1	expressed_in	gene	0.60
ERBB4	expressed_in	gene	0.60
Inflammation	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Als	associated_with	disease	0.60
Ms	regulates	disease	0.60
TRKB	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LONG-TERM POTENTIATION in their description or question text

No additional research found