gene

HDAC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

387Connections

4Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

HDAC2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Alzheimer. Connected to 161 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HDAC2
Full Name	Histone Deacetylase 2
Chromosome	6q21
Function	HDAC2 encodes histone deacetylase 2, a class I histone deacetylase that regulates gene expression through chromatin remodeling.
Primary Expression	neurons and plays critical roles in synaptic plasticity, memory formation, and transcriptional regulation
Pathways	Apoptosis, Dna Repair, Epigenetic, Hippo, Notch
UniProt ID	[Q92769](https://www.uniprot.org/uniprot/Q92769)
Ensembl ID	ENSG00000196591
OMIM	605185
GeneCards	HDAC2
Human Protein Atlas	HDAC2
Associated Diseases	Als, Alzheimer, Cancer, Colorectal Cancer, Gastric Cancer, Hepatocellular Carcinoma
Known Drugs/Compounds	SULFORAPHANE
Interactions	ACAT1, ACETYL-COA, Actin, Adiponectin, AKT, ALZHEIMER
SciDEX Hypotheses	Gut-derived butyrate reprograms microglia for amyl HDAC2-Specific Repression of PU.1 Pioneer Factor T Gut butyrate deficiency impairs microglial amyloid
KG Connections	387 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HDAC2 Gene

gene · 790 words

→

HDAC2 Protein — Histone Deacetylase 2

protein · 1386 words

→

Pathway Diagram

graph TD
    HDAC2["HDAC2"]
    HDAC2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    HDAC2 -->|"regulates"| Parkinson["Parkinson"]
    HDAC2 -->|"regulates"| Alzheimer["Alzheimer"]
    HDAC2 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    HDAC2 -->|"regulates"| Inflammation["Inflammation"]
    HDAC2 -->|"regulates"| Huntington["Huntington"]
    HDAC2 -->|"regulates"| Ms["Ms"]
    HDAC2 -.biomarker for.-> Als["Als"]
    HDAC2 -->|"activates"| Anxiety["Anxiety"]
    PLEKHG5["PLEKHG5"] -->|"interacts"| HDAC2
    SIRT6["SIRT6"] -->|"regulates"| HDAC2
    HDAC11["HDAC11"] -->|"expressed in"| HDAC2
    IKBKB["IKBKB"] -.biomarker for.-> HDAC2
    PIK3R1["PIK3R1"] -.biomarker for.-> HDAC2
    GENES["GENES"] -.biomarker for.-> HDAC2
    BDNF["BDNF"] -->|"regulates"| HDAC2
    HDAC3["HDAC3"] -->|"expressed in"| HDAC2
    SIRT5["SIRT5"] -->|"regulates"| HDAC2
    HDAC7["HDAC7"] -->|"expressed in"| HDAC2

Outgoing (228)

Target	Relation	Type	Str
LAPTM4B	associated_with	gene	0.98
Autophagy	regulates	process	0.95
Hepatocellular Carcinoma	associated_with	disease	0.92
Pro-Inflammatory Cytokines	regulates	protein	0.90
memory loss	causes	phenotype	0.80
epigenetic regulation	participates_in	pathway	0.80
Cancer	associated_with	disease	0.75
Colorectal Cancer	associated_with	disease	0.75
Epigenetic	regulates	pathway	0.70
miR-34a	targets	gene	0.70
Ms	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Leukemia	activates	disease	0.65
ALS	activates	disease	0.65
Cardiac	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Diabetes	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Cancer	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Tumor	activates	disease	0.65
AUTOPHAGY	associated_with	process	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
TAU	inhibits	protein	0.65
Anxiety	activates	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Gastric Cancer	associated_with	disease	0.65
Als	expressed_in	disease	0.65
HDAC3	associated_with	gene	0.65
Als	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	expressed_in	disease	0.65
NEURODEGENERATION	associated_with	concept	0.65
Aging	inhibits	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65

Incoming (159)

Source	Relation	Type	Str
MIR34A	targets	gene	0.95
MIR34A	downregulates	gene	0.90
Creatine Phosphate	downregulates	compound	0.85
PLEKHG5	interacts_with	gene	0.80
AKT	associated_with	gene	0.80
CANCER	associated_with	gene	0.70
β-hydroxybutyrate	inhibits	metabolite	0.70
SULFORAPHANE	inhibits	drug	0.65
HDAC1	associated_with	gene	0.65
ACETYL-COA	interacts_with	gene	0.60
CANCER	expressed_in	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
P53	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
HDAC	inhibits	gene	0.60
CREB	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
WNT	expressed_in	gene	0.60
RNA	activates	gene	0.60
CANCER	activates	gene	0.60
ACAT1	interacts_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
SIRT3	regulates	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC1	inhibits	gene	0.60
CAV1	activates	gene	0.60
BDNF	activates	gene	0.60
MAP2	activates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
HDAC8	therapeutic_target	gene	0.60
HDAC6	therapeutic_target	gene	0.60
CBP	regulates	gene	0.60
SIRT6	regulates	gene	0.60
HDAC11	expressed_in	gene	0.60
KDM1A	inhibits	gene	0.60
TAU	regulates	gene	0.60
GENES	regulates	gene	0.60
RUNX1	activates	gene	0.60
IL-6	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
ADNP	associated_with	gene	0.60
CP	regulates	gene	0.60
CP	inhibits	gene	0.60
HDAC1	activates	gene	0.60
GENES	biomarker_for	gene	0.60
ERK	activates	gene	0.60
KCNQ3	regulates	gene	0.60
EGFR	activates	gene	0.60
MECP2	regulates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC2 Phospho-Lock Window for Synaptic Gene Silencing	0.643	neurodegeneration	What is the optimal therapeutic window d
Gut-derived butyrate reprograms microglia for amyloid cleara	0.525	Alzheimer's disease	Gut-Brain Axis Therapeutics for AD
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e
Gut butyrate deficiency impairs microglial amyloid clearance	0.380	Alzheimer's disease	Gut-Brain Axis Therapeutics for Alzheime

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning HDAC2 in their description or question text

No additional research found