gene

Β-HYDROXYBUTYRATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Β-HYDROXYBUTYRATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

187Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	Β-HYDROXYBUTYRATE
Pathways	Inflammasome Complex, Apoptosis, Pyroptosis, Epigenetic, Autophagy
Associated Diseases	ALS, Alzheimer
Interactions	AGING, AIM2, ALZHEIMER'S DISEASE, AMPK, ANXIETY, APOPTOSIS
KG Connections	151 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -->|"activates"| ERBB3["ERBB3"]
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -.->|"inhibits"| Als["Als"]
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -->|"activates"| Osteoarthritis["Osteoarthritis"]
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -->|"activates"| Apoptosis["Apoptosis"]
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -.->|"inhibits"| Ischemia["Ischemia"]
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"] -.->|"inhibits"| Ms["Ms"]
    APOPTOSIS["APOPTOSIS"] -->|"activates"| __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"]
    PYROPTOSIS["PYROPTOSIS"] -.->|"inhibits"| __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"]
    SIRT1["SIRT1"] -.->|"inhibits"| __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"]
    FOXO3["FOXO3"] -.->|"inhibits"| __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"]
    style __HYDROXYBUTYRATE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (129)

Target	Relation	Type	Str
Microglia	regulates	cell_type	0.98
Cerebral Edema	associated_with	disease	0.95
Glymphatic System	associated_with	process	0.95
Cerebral Edema	treats	disease	0.95
Inflammasome Complex	inhibits	pathway	0.95
Pro-Inflammatory Mediators	downregulates	biomarker	0.93
Microgliosis	suppresses	phenotype	0.92
Neurodegeneration	treats	disease	0.92
ERBB3	activates	gene	0.90
Cognitive Function	upregulates	phenotype	0.88
Aβ Deposition	associated_with	biomarker	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Ischemic Stroke	treats	disease	0.85
Als	inhibits	disease	0.75
Osteoarthritis	activates	disease	0.75
Apoptosis	activates	pathway	0.70
mitochondrial metabolism	regulates	process	0.70
cellular aging	modulates	process	0.70
neuroprotection in immature brains	causes	phenotype	0.70
BDNF	activates	protein	0.70
autophagy pathway	regulates	pathway	0.70
mitochondrial metabolism	modulates	process	0.70
HDAC2	inhibits	enzyme	0.70
HDAC3	inhibits	enzyme	0.70
BDNF expression	activates	process	0.70
autophagy	modulates	pathway	0.70
epigenetic regulation	modulates	pathway	0.70
ischemic brain injury	protective_against	disease	0.70
oxidative stress	reduces	mechanism	0.70
neuroinflammation	reduces	mechanism	0.70
astrocytic glucose consumption	inhibits	process	0.70
astrocytic glycolysis	inhibits	pathway	0.70
IRAKM	regulates	protein	0.70
Anxiety	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Aging	treats	disease	0.65
Inflammation	treats	disease	0.65
Inflammation	regulates	disease	0.65
Melanoma	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Stroke	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Diabetes	regulates	disease	0.65
ALS	associated_with	disease	0.65

Incoming (58)

Source	Relation	Type	Str
29219210	inhibits	paper	0.90
29219210	activates	paper	0.90
APOPTOSIS	activates	gene	0.70
34684426	serves as epigenetic regulator in terms of	paper	0.60
TERT	activates	gene	0.60
PINK1	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
34684426	acts as a signaling molecule of modulating	paper	0.60
NLRP3	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
ASC	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
SIRT2	inhibits	gene	0.60
AIM2	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NLRC4	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ROS	inhibits	gene	0.60
ANXIETY	activates	gene	0.60
HDAC3	activates	gene	0.60
BDNF	activates	gene	0.60
ERBB3	activates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
PARKINSON'S DISEASE	protects_against	gene	0.60
APOPTOSIS	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
PARKINSON	protects_against	gene	0.60
NEURODEGENERATIVE DISEASES	protects_against	gene	0.60
MITOCHONDRIAL DYSFUNCTION	protects_against	gene	0.60
ACETYL-COA	protects_against	gene	0.60
HDAC	activates	gene	0.60
HDAC2	activates	gene	0.60
PCK1	regulates	gene	0.60
CD8	regulates	gene	0.60
GPR109A	protects_against	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GPR109A	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
GPR109A	associated_with	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
FOXO3	inhibits	gene	0.60
TRKB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the optimal timing and dosing of ketogenic interventions for neu

metabolic neuroscience | 2026-04-03 | 7 hypotheses Top: 0.773

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While ketone metabolism was discussed as therapeutic, the debate revealed no cle

closed · Rounds: 4 · Score: 0.80 · 2026-04-03

Related Research

Hypotheses and analyses mentioning Β-HYDROXYBUTYRATE in their description or question text

No additional research found