gene

CHMP1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

7Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for CHMP1B — Charged Multivesicular Body Protein 1B

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🧬 Gene Info

Gene Symbol	CHMP1B
Full Name	Charged Multivesicular Body Protein 1B
Chromosome	18q23
Function	is a component of the ESCRT-III (Endosomal Sorting Complex Required for Transport-III) machinery, essential for endosomal membrane remodeling and multivesicular body (MVB) formation.
Molecular Weight	22 kDa
Amino Acids	199 aa
UniProt ID	[Q9Y3Q1](https://www.uniprot.org/uniprot/Q9Y3Q1)
Ensembl ID	ENSG00000086205
GeneCards	CHMP1B
Human Protein Atlas	CHMP1B
Associated Diseases	neurodegeneration
Interactions	AND, C-JUN, JNK, JUN, ROS, UBIQUITIN
KG Connections	10 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHMP1B — Charged Multivesicular Body Protein 1B

gene · 2062 words

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Pathway Diagram

graph TD
    CHMP1B["CHMP1B"]
    Hepatitis{"Hepatitis"}
    CHMP1B -->|"activates"| Hepatitis
    JUN["JUN"]
    CHMP1B -->|"activates"| JUN
    VPS4A["VPS4A"]
    CHMP1B -->|"activates"| VPS4A
    neurodegeneration["neurodegeneration"]
    CHMP1B -->|"implicated in"| neurodegeneration
    C_JUN["C-JUN"]
    C_JUN -->|"activates"| CHMP1B
    style CHMP1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Hepatitis	activates	disease	0.65
Infection	interacts_with	disease	0.65
ROS	activates	gene	0.60
JUN	activates	gene	0.60
VPS4A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
JNK	activates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
AND	activates	gene	0.60
JUN	activates	gene	0.60
C-JUN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHMP1B in their description or question text

No additional research found